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Douglas E. Brenneman

Johnson & Johnson Pharmaceutical Research and Development

33

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Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

2013 Journal of Medicinal Chemistry
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Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.

2010 Bioorganic & Medicinal Chemistry Letters
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Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons

2009 Epilepsy Research
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Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Advancement of N-((Benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into Human Clinical Studies

2009 Journal of Medicinal Chemistry
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Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations

2007 Journal of Neuroscience Methods
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Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant-submissive relationships.

2007 Neuroscience & Biobehavioral Reviews
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Neuroprotection : A comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide

2007 Peptides
- Douglas E. Brenneman
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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

2007 Journal of Medicinal Chemistry
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Neonatal mice of the down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation

2006 Journal of Molecular Neuroscience
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A Novel VIP Responsive Gene: Activity Dependent Neuroprotective Protein

2006 Annals of the New York Academy of Sciences
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Citations (32)