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Yasutaka Hoashi

Takeda Pharmaceutical Company

14

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1042

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Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.

2021 Journal of Medicinal Chemistry
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Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts

2018 Oncology Letters
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Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists

2018 Bioorganic & Medicinal Chemistry
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Anti-tumor activity of KNTC2 siRNA in orthotopic tumor model mice of hepatocellular carcinoma

2017 Biochemical and Biophysical Research Communications
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Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ42 production

2015 Bioorganic & Medicinal Chemistry
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Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.

2015 Bioorganic & Medicinal Chemistry Letters
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Synthesis of a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]pyridine derivative, the 5-aza analog of ramelteon

2014 Tetrahedron Letters
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Synthesis of a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]pyridine derivative, the 5-aza analog of ramelteon

2014 Tetrahedron Letters
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Synthesis of 4-aza analog of ramelteon: a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridine derivative as melatonin receptor ligand

2011 Tetrahedron Letters
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Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as Melatonin Receptor (MT1/MT2) Ligands

2011 Journal of Medicinal Chemistry
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Citations (51)