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Cheng Liao

Hoffmann-La Roche

10

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355

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Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors

2014 Journal of Medicinal Chemistry
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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy

2013 Arthritis Research & Therapy
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Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.

2013 Journal of Medicinal Chemistry
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Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling

2013 Journal of Biomolecular Screening
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Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders: Recent progress and therapeutic perspectives

2013 Pharmacology & Therapeutics
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3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

2013 Journal of Medicinal Chemistry
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Rational design of highly selective spleen tyrosine kinase inhibitors.

2012 Journal of Medicinal Chemistry
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Citations (34)