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Sandra Wang

Hoffmann-La Roche

9

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304

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691 MDK-271: A dual function molecule consisting of empirically-designed peptidyl agonists of IL-2/15Rβγc and IL-7Rαγc, unrelated to IL-2, IL-15, or IL-7, incorporated into a bispecific Fc fusion protein

2020 Journal for ImmunoTherapy of Cancer
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566 MDK-202: An empirically-designed peptidyl agonist of the IL-2/15βγc receptor, devoid of Rα interaction, unrelated to IL-2 or IL-15, and fused to an Fc-domain for PK enhancement

2020 Journal for ImmunoTherapy of Cancer
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567 MDK1319/MDK-701: A potent fully efficacious peptidyl agonist of IL-7Rαγc, designed with no reference to cytokine or receptor structure and unrelated to IL-7, fused to an Fc-domain for PK enhancement

2020 Journal for ImmunoTherapy of Cancer
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3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

2013 Journal of Medicinal Chemistry
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Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-D-2′-ethynyl-7-deaza-adenosine triphosphate.

2010 Antiviral Research
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Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.

2009 Chemical Biology & Drug Design
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The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity.

2008 Journal of Molecular Biology
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Molecular Mechanism of the Syk Activation Switch

2008 Journal of Biological Chemistry
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Steady State Kinetics of Spleen Tyrosine Kinase Investigated by a Real Time Fluorescence Assay

2007 Biochemistry
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