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Takeshi Kunimatsu

Dainippon Sumitomo Pharma Co., Ltd.

25

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541

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Mo1073 - The Novel 5-HT 4 Receptor Agonist, DSP-6952, Has a Favorable Cardiovascular Profile in In Vitro Assays and In Vivo Experimental Animals

2018 Gastroenterology
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The in vitro pharmacology and non-clinical cardiovascular safety studies of a novel 5-HT4 receptor agonist, DSP-6952

2018 European Journal of Pharmacology
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CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information

2017 Regulatory Toxicology and Pharmacology
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CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability.

2016 Regulatory Toxicology and Pharmacology
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Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

2016 Journal of Pharmacological and Toxicological Methods
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Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats

2014 Toxicology in Vitro
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Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study.

2014 Toxicology and Applied Pharmacology
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Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation

2014 Toxicology and Applied Pharmacology
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Measurement of short-circuit current in the rat inner medullary collecting duct for evaluation of plasma expansion

2013 Journal of Pharmacological and Toxicological Methods
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Evaluation of ovarian toxicity of mono-(2-ethylhexyl) phthalate (MEHP) using cultured rat ovarian follicles.

2012 Journal of Toxicological Sciences
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Citations (44)