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Nobuo Cho

Takeda Pharmaceutical Company

31

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990

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Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.

2021 Journal of Medicinal Chemistry
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Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

2019 Science Advances
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Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)

2019 Chemical & Pharmaceutical Bulletin
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Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

2018 Scientific Reports
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Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

2018 Journal of Biological Chemistry
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Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands

2017 Cancer Science
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Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation

2017 ACS Medicinal Chemistry Letters
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In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

2017 Journal of Biological Chemistry
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2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase

2017 Bioorganic & Medicinal Chemistry
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Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones

2017 Bioorganic & Medicinal Chemistry
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Citations (9)