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Hideto Hara
Hideto Hara
Takeda Pharmaceutical Company
Chemistry
Biochemistry
Stereochemistry
Pharmacophore
Moiety
5
Papers
33
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Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent.
2020
Journal of Medicinal Chemistry
Osamu Kurasawa
Tohru Miyazaki
Misaki Homma
Yuya Oguro
Takashi Imada
Noriko Uchiyama
Kenichi Iwai
Yukiko Yamamoto
Momoko Ohori
Hideto Hara
Hiroshi Sugimoto
Kentaro Iwata
Robert J. Skene
Isaac D. Hoffman
Akihiro Ohashi
Toshiyuki Nomura
Nobuo Cho
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Citations (9)
Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity
2019
Chemical Research in Toxicology
Tomoya Sameshima
Tomoya Yukawa
Yoshihiko Hirozane
Masato Yoshikawa
Taisuke Katoh
Hideto Hara
Takatoshi Yogo
Ikuo Miyahisa
Teruaki Okuda
Makoto Miyamoto
Russell Naven
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Citations (3)
Predicting Strategies for Lead Optimization via Learning to Rank
2018
Ipsj Transactions on Bioinformatics
Nobuaki Yasuo
Keisuke Watanabe
Hideto Hara
Kentaro Rikimaru
Masakazu Sekijima
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Citations (3)
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones
2017
Bioorganic & Medicinal Chemistry
Osamu Kurasawa
Yuya Oguro
Tohru Miyazaki
Misaki Homma
Kouji Mori
Kenichi Iwai
Hideto Hara
Robert J. Skene
Isaac D. Hoffman
Akihiro Ohashi
Sei Yoshida
Tomoyasu Ishikawa
Nobuo Cho
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Citations (9)
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase
2017
Bioorganic & Medicinal Chemistry
Osamu Kurasawa
Misaki Homma
Yuya Oguro
Tohru Miyazaki
Kouji Mori
Noriko Uchiyama
Kenichi Iwai
Akihiro Ohashi
Hideto Hara
Sei Yoshida
Nobuo Cho
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Citations (9)
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