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Michael Stumm

Novartis

28

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1833

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First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13)

2018 European Journal of Cancer
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Abstract 2287: Final results of the pharmacodynamic (PD) data of PQR309-001, a first-in-human trial of a combined PI3K/mTOR inhibitor in advanced solid tumors

2016 Cancer Research
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A phase 1 first-in-human (FIH) dose-escalation (DE) study of the oral dual PI3K/mTOR inhibitor PQR309 in patients (pts) with advanced solid tumors: Final DE results.

2015 Journal of Clinical Oncology
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Early preclinical development of PQR309, a novel balanced dual PI3K/mTOR inhibitor for treatment of various cancer types

2015 Toxicology Letters
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Validation of a Postfixation Tissue Storage and Transport Medium to Preserve Histopathology and Molecular Pathology Analyses (Total and Phosphoactivated Proteins, and FISH)

2012 American Journal of Clinical Pathology
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Quantified tumor t1 is a generic early-response imaging biomarker for chemotherapy reflecting cell viability.

2010 Clinical Cancer Research
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Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PET

2010 Translational Oncology
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Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor-Positive Breast Cancer

2009 Journal of Clinical Oncology
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Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

2008 Cancer Research
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Evaluation of a recently available high throughput automated image analysis application to determine proliferation indices on virtual slides

2008 Cancer Research
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