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Theodore J. Detwiler

Merck & Co.

8

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Evaluation of clinically-relevant proarrhythmic ECG biomarkers in conscious beagle dogs using a newly developed multiple lead ECG telemetry implant

2018 Journal of Pharmacological and Toxicological Methods
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Measurement of heart rate variability (HRV) and spontaneous baroreflex sensitivity (sBRS) provides valuable information on compound-dependent cardiovascular effects to enhance safety risk assessment

2018 Journal of Pharmacological and Toxicological Methods
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Development and characterization of a nerve conduction model in anesthetized non-human primates as a tool to assess compound-dependent peripheral nervous system risk

2018 Journal of Pharmacological and Toxicological Methods
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Effect of Calcitonin Gene-Related Peptide Receptor Antagonism on the Systemic Blood Pressure Responses to Mechanistically Diverse Vasomodulators in Conscious Rats

2010 Journal of Cardiovascular Pharmacology
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Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B1 Receptor Antagonists

2006 Journal of Medicinal Chemistry
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thrombin-hirugen_l-378,650

2004
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Crystal Structure of Thrombin in Complex with L-378,622

2004
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