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Scott L. Harbeson

Vertex Pharmaceuticals

37

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A Decade of Deuteration in Medicinal Chemistry

2017 Annual Reports in Medicinal Chemistry
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Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor With Differentiated Pharmacokinetics for Clinical Development

2017 Journal of Pharmacology and Experimental Therapeutics
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WS13.6 CTP-656 tablet confirmed superiority of pharmacokinetic profile relative to Kalydeco® in Phase I clinical studies

2016 Journal of Cystic Fibrosis
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Altering Metabolic Profiles of Drugs by Precision Deuteration: Reducing Mechanism-Based Inhibition of CYP2D6 by Paroxetine

2015 Journal of Pharmacology and Experimental Therapeutics
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Deuterium Medicinal Chemistry: A New Approach to Drug Discovery and Development

2014
- Scott L. Harbeson
- Roger D. Tung
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Identification and structural elucidation of in vitro metabolites of atazanavir by HPLC and tandem mass spectrometry

2013 Journal of Mass Spectrometry
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Design and synthesis of deuterated boceprevir analogs with enhanced pharmacokinetic properties

2011 Journal of Labelled Compounds and Radiopharmaceuticals
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Citations (9)
Deuterium in Drug Discovery and Development

2011 Annual Reports in Medicinal Chemistry
- Scott L. Harbeson
- Roger D. Tung
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Compounds of pyrazinoisoquinoline

2010
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Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux

2008
- Scott L. Harbeson
- Craig E. Masse
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