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Hitoshi Iikura

Chugai Pharmaceutical Co.

24

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COMPOSÉ PEPTIDE CYCLIQUE À HAUTE PERMÉABILITÉ DE MEMBRANE ET BIBLIOTHÈQUE CONTENANT CELUI-CI

2018
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チオール基をアミノ基近傍に有するアミノ酸をＮ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法

2017
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Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

2013 Cancer Research
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Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

2013 ACS Medicinal Chemistry Letters
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Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF

2011 Cancer Research
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Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

2011 Bioorganic & Medicinal Chemistry Letters
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Design and synthesis of peptidomimetic factor VIIa inhibitors.

2010 Chemical & Pharmaceutical Bulletin
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Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination.

2008 Bioorganic & Medicinal Chemistry Letters
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INDUCTEUR DE PROTÉINE p27

2008
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２，３，４－トリフルオロ－５－（ヨード又はブロモ）安息香酸の製造方法

2006
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