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Matti Lepistö

AstraZeneca

32

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359

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AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.

2021 Journal of Medicinal Chemistry
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Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

2020 Science Advances
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Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design

2018 Journal of Medicinal Chemistry
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1H, 13C, 15N backbone and 1H, 13C methionine methyl chemical shifts of human wildtype Glucocorticoid receptor Ligand Binding Domain

2018 Journal of Back and Musculoskeletal Rehabilitation
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Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile

2018 Journal of Medicinal Chemistry
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Backbone 1 H, 13 C, and 15 N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant

2018 Biomolecular Nmr Assignments
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Saccharin Aza Bioisosteres—Synthesis and Preclinical Property Comparisons

2017 ACS Medicinal Chemistry Letters
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Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators

2017
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Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.

2016 Bioorganic & Medicinal Chemistry Letters
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GR in complex with dexamethasone

2015
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