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Concepción Pedregal

Eli Lilly and Company

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.

2015 Journal of Medicinal Chemistry
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LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

2014 Neuropharmacology
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Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3-c]pyran) Scaffold

2014 Journal of Medicinal Chemistry
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A novel N/OFQ antagonist that is potent, selective, orally-bioavailable, and has demonstrable on-target actions (656.4)

2014 The FASEB Journal
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Development of LC-MS/MS-Based Receptor Occupancy Tracers and Positron Emission Tomography Radioligands for the Nociceptin/Orphanin FQ (NOP) Receptor

2012 Journal of Medicinal Chemistry
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Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

2011 Journal of Medicinal Chemistry
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Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography

2011 Journal of Medicinal Chemistry
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Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors

2011 The Journal of Nuclear Medicine
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Efficient Synthesis of 4-Methylene-L-glutamic Acid (V) and Its Cyclopropyl Analogue

2010 ChemInform
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2,3′-Disubstituted-2-(2′-carboxycyclopropyl)glycines as Potent and Selective Antagonists of Metabotropic Glutamate Receptors.

2010 ChemInform
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