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Simon A. Osborne

Medical Research Council Technology

21

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Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs

2020 Frontiers in Microbiology
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Development of Chemical Entities Endowed with Potent Fast- Killing Properties against Plasmodium falciparum Malaria Parasites

2019 Journal of Medicinal Chemistry
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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

2019 Bioorganic & Medicinal Chemistry Letters
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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

2019 Bioorganic & Medicinal Chemistry Letters
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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

2017 Nature Communications
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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

2016 Antimicrobial Agents and Chemotherapy
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Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

2015 Journal of Biological Chemistry
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Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

2014 Antimicrobial Agents and Chemotherapy
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Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

2014 Journal of Medicinal Chemistry
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In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.

2009 Bioorganic & Medicinal Chemistry Letters
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Citations (17)