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Keith Biggadike

University of Hertfordshire

54

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Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.

2016 Journal of Medicinal Chemistry
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Pyrrolo [3,2-d] pyrimidine as inducers of human interferon

2015
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Single and repeat dose safety and pharmacodynamics studies with the selective intranasal TLR7 agonist GSK2245035

2014 European Respiratory Journal
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Discovery of a Rapidly Metabolized, Long-Acting β2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

2014 Journal of Medicinal Chemistry
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Carboxamides de n-cyclo-butylimidazopyridine ou de n-cyclo-pyrazolopyridine comme antagonistes de trpv1

2011
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Carboxamides de n-cyclo-butylimidazopyridine ou de n-cyclo-pyrazolopyridine comme antagonistes de trpv1

2011
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Novel Glucocorticoid Antedrugs Possessing a 21-(?-Lactone) Ring.

2010 ChemInform
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Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

2010 Journal of Medicinal Chemistry
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Novel Glucocorticoid Antedrugs Possessing a C16,17-Fused γ-Lactone Ring.

2010 ChemInform
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Purinderivate zur verwendung bei der behandlung allergischer, entzündlicher und infektiöser krankheiten

2009
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