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Simon J. Dowell

GlaxoSmithKline

25

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809

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G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

2020 Scientific Reports
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N‐Palmitoylglycine and other N‐acylamides activate the lipid receptor G2A/GPR132

2019 Pharmacology Research & Perspectives
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Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

2016 Journal of Biological Chemistry
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Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

2016 Journal of Medicinal Chemistry
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Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity

2016 Journal of Medicinal Chemistry
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Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)

2015 Journal of Biological Chemistry
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Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor

2013 British Journal of Pharmacology
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A High-Throughput Assay for Connexin 43 (Cx43, GJA1) Gap Junctions Using Codon-Optimized Aequorin

2013 Assay and Drug Development Technologies
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Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs.

2013 Biochimica et Biophysica Acta
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The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.

2012 Xenobiotica
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Citations (9)