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James Ropa

University of Michigan

18

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147

Citations

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Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.

2021 Nature Communications
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Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis.

2021 Cancers
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The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation

2019 Stem cell reports
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PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia

2018 Oncotarget
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The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia

2018 Oncogene
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p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

2018 Nature Communications
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SETDB1 Represses Hox Gene Expression and Suppresses Acute Myeloid Leukemia

2018 Blood
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Abstract 5489: Using genetic and chemical approaches to probe the mechanism of DOT1L recruitment in MLL fusion leukemia

2017 Cancer Research
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The AF9-Binding Domain of DOT1L Is Critical for Its Recruitment By MLL Fusion Proteins in Leukemia and Contributes to Its Functions in Normal Hematopoiesis

2017 Blood
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Abstract 3803: Development of genetic and chemical tools for understanding the recruitment of DOT1L in MLL-fusion driven leukemia and normal hematopoiesis

2016 Cancer Research
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