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Trupta Purohit

University of Michigan

33

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1270

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Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.

2021 Nature Communications
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EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing sarcoma

2021 Molecular Cancer Research
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.

2021 Nature Chemical Biology
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Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.

2020 European Journal of Medicinal Chemistry
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Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML with activating FLT3 mutations.

2020 Blood
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861 CCN2/Connective tissue growth factor regulates G1 to S phase cell cycle progression in human skin fibroblasts

2018 Journal of Investigative Dermatology
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Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

2017 MedChemComm
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Abstract 5077: A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias

2017 Cancer Research
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Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts

2017 PLOS ONE
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Abstract 50: Small molecule Ring1B-Bmi1 inhibitor attenuates PRC1 E3 ligase activity and targets leukemia stem cells self-renewal

2017 Clinical Cancer Research
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