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Michael A. Watson

GlaxoSmithKline

22

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7243

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Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

2008 Journal of Medicinal Chemistry
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The Relative Transcription Index: A Gene Expression Based Metric for Prioritization of Drug Candidates

2007 Combinatorial Chemistry & High Throughput Screening
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Liver X receptors are regulators of adipocyte gene expression but not differentiation identification of apoD as a direct target

2004 Journal of Lipid Research
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Williams, S. et al. X-ray crystal structure of the liver X receptor ligand binding domain: regulation by a histidine-tryptophan switch. J. Biol. Chem. 278, 27138-27143

2003
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Recombinant Baculoviruses Used to Study Estrogen Receptor Function in Human Osteosarcoma Cells

2003 Assay and Drug Development Technologies
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Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

2003 Proceedings of the National Academy of Sciences of the United States of America
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Citations (170)
Procedes de traitement au moyen de modulateurs lxr

2003
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Verfahren zur behandlung mit lxr-modulatoren

2003
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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 Proceedings of the National Academy of Sciences of the United States of America
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Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines

2002 Journal of Medicinal Chemistry
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Citations (367)