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Christophe Mellon

Merck & Co.

19

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353

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Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

2014 Antimicrobial Agents and Chemotherapy
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Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: Cellular distribution in human leukocyte populations and evidence of diurnal modulation

2011 Analytical Biochemistry
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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

2010 Journal of Medicinal Chemistry
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Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease.

2010 Bioorganic & Medicinal Chemistry Letters
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

2010 Bioorganic & Medicinal Chemistry Letters
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Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.

2008 Journal of Medicinal Chemistry
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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

2007 Bioorganic & Medicinal Chemistry Letters
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Inhibiteurs de la cystéine protéase de la famille de la papaïne pour le traitement des maladies parasitaires

2006
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COMPOSES TRICYCLIQUES UTILISES COMME INHIBITEURS DE KINASES

2006
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Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

2005 Bioorganic & Medicinal Chemistry Letters
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Citations (11)