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Todd Robert Ryder

Pfizer

16

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164

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Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.

2013 Journal of Medicinal Chemistry
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Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

2013 Bioorganic & Medicinal Chemistry Letters
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2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.

2013 Bioorganic & Medicinal Chemistry Letters
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Crystal structure of human Arginase-2 complexed with inhibitor 11d: {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)

2013
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Inhibiteurs d'arginase et leurs applications thérapeutiques

2011
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The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

2006 Bioorganic & Medicinal Chemistry Letters
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Inhibiteurs d'aminotransferase acides amines-dependante a chaine ramifiée, et leur utilisation dans le cadre d'un traitement de maladies neurodégénératives

2002
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Inhibitors dependent BCAA and use in neurodegenerative diseases tratamientyo aminotransferase.

2001
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Neuronal N-type calcium channel blockers: a series of 4-piperidinylaniline analogs with analgesic activity.

2000 Drug Design and Discovery
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Synthesis and biological activity of 4-aminopiperidine derivatives as N- type calcium channel antagonists

2000 Medicinal Chemistry Research
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