Inhibitors dependent BCAA and use in neurodegenerative diseases tratamientyo aminotransferase.

A compound of Formula I, wherein R3 is H, or F, Br, alkyl, carboxy, alkoxy, substituted alkoxy, R1, R2, R4 and R5 are independently H, halogen, alkyl, substituted alkyl, alkoxy, substituted, cyano, nitro, amino, alkylamine, and thioalkyl, Ar is bicyclic heteroaryl, tricyclic heteroaryl, substituted bicyclic heteroaryl, except (6-methoxybenzofuran) -2-yl, 3-quinolinyl; being selected from the group consisting of Ar: wherein R6 is alkoxy, substituted alkoxy, halogen, aryloxy, substituted aryloxy, alkylamino, substituted alkylamino, arylalkylamino, arylalkylamino substituted amide or substituted amide; or a salt, ester or amide pharmaceutically acceptable same.