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Daniela Borghi

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Identification of unprecedented ATP-competitive choline kinase inhibitors.

2021 Bioorganic & Medicinal Chemistry Letters
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Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy.

2015 Journal of Medicinal Chemistry
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Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor

2015
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Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.

2014 Journal of Medicinal Chemistry
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Derivatives 3-oxo-2,3-dihydro-1H-indazol-4-carboxamide as inhibitors of PARP-1

2012
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Total Synthesis of (+)-7,11-Helianane and (+)-5-Chloro-7,11-helianane through Stereoselective Aromatic Claisen Rearrangement

2011 European Journal of Organic Chemistry
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Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing.

2010 Bioorganic & Medicinal Chemistry
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Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin

2009 Tetrahedron
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Total synthesis of (±)-cyclooroidin

2005 Tetrahedron Letters
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Total synthesis of (±)-cyclooroidin

2005 Tetrahedron Letters
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