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Robert J. Leadley

Pfizer

38

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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

2009 Bioorganic & Medicinal Chemistry
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A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes

2008 Cardiovascular Drugs and Therapy
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Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis

2008 Thrombosis and Haemostasis
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The Discovery of (2R,4R)‐N‐(4‐chlorophenyl)‐N‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2H)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

2007 Chemical Biology & Drug Design
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Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients

2007 Thrombosis and Haemostasis
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The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors

2006 Bioorganic & Medicinal Chemistry
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Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro

2006 Journal of Thrombosis and Haemostasis
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Dual Inhibition of Blood Coagulation Factors Xa and Iia Synergize To Reduce Thrombus Weight and Thrombin Generation in a Rabbit Arteriovenous Shunt Model of Thrombosis.

2005 Blood
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The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2

2005 Bioorganic & Medicinal Chemistry Letters
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Inhibition of Factors Xa and Iia Results in Synergistic Inhibition of Thrombin Generation with Minimal Clot Time Elevation.

2005 Blood
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