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Eric C. Hales
Eric C. Hales
Wayne State University
Biology
PTEN
Protein kinase B
PI3K/AKT/mTOR pathway
Cancer research
8
Papers
236
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Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11
2019
Toxics
Jeremiah N. Shields
Eric C. Hales
Lillian E. Ranspach
Xixia Luo
Steven Orr
Donna L. Runft
Alan A. Dombkowski
Melody N. Neely
Larry H. Matherly
Jeffrey W. Taub
Tracie R. Baker
Ryan Thummel
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Citations (5)
Discovery of 5-substituted pyrrolo[2,3- d ]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: Implications of inhibiting 5-aminoimidazole-4- carboxamide ribonucleotide formyltransferase to AMPK activation and antitumor activity
2013
Journal of Medicinal Chemistry
Shermaine Mitchell-Ryan
Yiqiang Wang
Sudhir Raghavan
Manasa Ravindra
Eric C. Hales
Steven Orr
Christina Cherian
Zhanjun Hou
Larry H. Matherly
Aleem Gangjee
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Citations (27)
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
2011
Molecular Pharmacology
Sita Kugel-Desmoulin
Lei Wang
Eric C. Hales
Lisa Polin
Kathryn White
Juiwanna Kushner
Mark Stout
Zhanjun Hou
Christina Cherian
Aleem Gangjee
Larry H. Matherly
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Citations (48)
Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL
2011
Cancer Research
Eric C. Hales
Amanda Larson Gedman
Yubin Ge
Jeffrey W. Taub
Larry H. Matherly
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