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Laura Carter

Trudeau Institute

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Phase 1 Open-Label, Multicenter Study of First-in-Class RORγ Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity

2019 Clinical Cancer Research
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Lyc-55716: A novel small-molecule RORγ agonist immuno-oncology agent: Rationale for tumor selection and clinical evaluation of gastric and esophageal carcinoma in phase 2a expansion.

2018 Journal of Clinical Oncology
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A Novel Immunotherapy: LYC-55716, a Small-molecule RORγ Agonist, in Clinical Trials for Head and Neck Squamous Cell Carcinoma

2018 International Journal of Radiation Oncology Biology Physics
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Novel small-molecule RORγ agonist immuno-oncology agent LYC-55716: Tumor selection and evaluation of renal cell and bladder cancer for inclusion in phase 2a expansion.

2018 Journal of Clinical Oncology
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Abstract 3777: RORγ agonist enhances antitumor effects of immune checkpoint anti-PD1

2018 Cancer Research
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In vitro priming of adoptively transferred T cells with a RORγ agonist confers durable memory and stemness in vivo

2018 Cancer Research
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1139PDNovel small-molecule RORγ agonist immuno-oncology agent LYC-55716: Safety and efficacy in a phase IIA open-label, multicenter trial

2018 Annals of Oncology
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RORγ agonist LYC-55716, a novel small molecule immunotherapy: Rationale for clinical evaluation in non-small cell lung cancer based on translational and bioinformatic evaluation.

2018 Journal of Clinical Oncology
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Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis

2017 Journal of Immunology
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Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

2016 Cell Reports
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Citations (45)