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Paul Hales

Takeda Pharmaceutical Company

8

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180

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Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.

2021 Proceedings of the National Academy of Sciences of the United States of America
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Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

2018 Journal of Medicinal Chemistry
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Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

2017 PLOS ONE
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Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

2016 Toxicology Research
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KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

2015 PLOS ONE
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227 Association of K-Ras Genotype with Xenograft Tumor Response to the Investigational Proteasome Inhibitor MLN9708

2012 European Journal of Cancer
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Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.

2011 Clinical Cancer Research
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Citations (90)