Determination of Trace Metals in Biological Samples by Inductively Coupled Plasma Mass Spectrometry
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An analytical method has been developed to determine trace elements in biological samples. The biological samples are added to a laboratory-bulit Teflon bomb together with nitric acid-hydrogen peroxide mixture and enriched stable isotopes. The samples are decomposed in a microwave oven. The decomposed sample solutions are analyzed by isotope dilution inductively coupled plasma mass spectrometry. The analytical results of the biological samples agree well with the reference values.Keywords:
Isotope dilution
Microwave digestion
Nitric acid
Microwave oven
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Abstract Abstract Three techniques for biological and agricultural sample preparation are compared. Commercially available inductively coupled argon plasma (ICAP) direct-reading spectrometers have been used to determine 29 major, minor, and trace elements in biological or agricultural samples following a nitric-perchloric acid digestion. At levels below the detection limit of the instrument, 21 other elements were found. The hydride generation-ICAP technique was employed for the determination of As, Bi, Sb, and Se in the same sample types.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable isotope dilution analysis of hydrologic samples by inductively coupled plasma mass spectrometryJohn R. Garbarino and Howard E. TaylorCite this: Anal. Chem. 1987, 59, 11, 1568–1575Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ac00138a018https://doi.org/10.1021/ac00138a018research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Isotope dilution
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The application of inductively coupled plasma quadrupole mass spectrometry (ICP QMS) for trace metal (Mo and Cd) determination in biological materials has been investigated after microwave digestion. The samples were digested in concentrated nitric acid in a high pressure microwave at 900 Watt within 20 min.Two modes of detector (pulse and dual) were compared to obtain the optimal conditions. External calibration was used in combination with Indium (10 ng/mL) as an internal standard. In order to test the accuracy and precision of the analytical technique, three standard reference materials were analyzed. The result obtained by ICP QMS for the metals considered showed good agreement with certified values.
Microwave digestion
Certified reference materials
Nitric acid
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We examined the method of sample digestion and the analytical conditions for simultaneous multi-determination of trace element concentrations by inductively coupled plasma mass spectrometry (ICP-MS) in biological samples. In order to eliminate contaminations by extraneous elements from reagents and instruments, we chose plastic tubes and a Teflon decomposition vessel and super pure grade nitric acid for sample decomposition. Furthermore, standard solutions were prepared by mixing stock solutions of trace elements with a mixture of sample solutions to eliminate matrix interference. Quality control measurements using a standard reference material (SRM bovine liver) showed that the multi-analysis method established in the present study is very accurate and useful for determination of trace element concentrations in biological samples. Using this procedure, we determined the distribution of Zn, Cu, Rb, Mn and Mo in seven discrete regions of the rat brain and Zn and Mn in their synaptosomal fractions.
Trace element
Nitric acid
Matrix (chemical analysis)
Standard addition
Sample Preparation
Standard solution
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A method for the determination of trace rhenium in geological samples (pyrites and rocks) using isotope dilution-inductively coupled plasma mass spectrometry was developed. Carius tube digestion method was used for sample preparation. The total procedure blanks could be limited in the range of 1. 4 - 10 pg. The method was verified by analyzing the national standard reference molybdenite sample and the result was in good agreement with the certified value (17. 39±0. 32) μg/g. The method has been applied to the determination of trace Re (1.27 ng/g) in rock sample with precision of 3. 89% RSD(n=4, 2s).
Isotope dilution
Molybdenite
Certified reference materials
Sample Preparation
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Abstract Inductively coupled plasma mass spectrometry using solution nebulization has the ability to analyze up to 70 elements with good precision, accuracy, and sensitivity and is, therefore, well suited for the trace element analysis of glass. However, the technique places severe restrictions on sample preparation. High concentrations of acids or dissolved solids, changes in sample viscosity and molecular compound formation can cause physical, spectral and chemical interference. Solubilization of the glass samples based on a three acid digestion procedure (HF, HNO3, HCl 2:1:1) has been found to minimize these problems. Up to 62 elements have been determined in a range of glass samples. Glasses that could not be distinguished on the basis of refractive index measurement could be discriminated. A procedure of measuring a range of elemental ratios, which eliminated the need for weighing, was used to compare small samples typical of casework.
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Microwave digestion
Ashing
Aqua regia
Matrix (chemical analysis)
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A method has been developed for the determination of trace elements in water and biological samples by inductively coupled plasma atomic emission spectrometry after pre-concentration with ammonium pyrrolidinedithiocarbamate [ammonium tetramethylenedithiocarbamate (APDC)] precipitation. The biological samples were decomposed under pressure with a mixture of nitric and perchloric acids. The optimum conditions used for the pre-concentration were as follows: the acidity of the sample solutions, prepared by the decomposition method, and of the water samples, 2%V/V HClO4; and APDC solution added for precipitation, 2 ml of 8%m/V. Quantitative recoveries for Cd, Co, Cu, Pb, Mo and Ni were achieved. The method has been applied to the determination of trace elements in water, sea water and National Bureau of Standards biological standard reference materials. Good agreement is achieved between the data obtained with the proposed method and literature values.
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The application of inductively coupled plasma mass spectrometry for water samples(surface water,drinking water,etc.),copper,zinc,selenium,arsenic,cadmium,chromium,lead,iron,manganese and other trace elements were analyzed.The results showed that the detection limit was 0.01~0.78 μg/L,the relative standard deviation of parallel samples was 0.6% to 7.9%,and the recovery of added standards in water samples ranged from 90.5% to 103%.The method was rapid,simple,linear range and good detection limits and accuracy.
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The rice samples after digested were treated by different chemical methods in this work. The experimental results measured by inductively coupled plasma mass spectrometry(ICP-MS)showed that the sample treated by sulphuric acid,hydrofluoric acid and hydrogen peroxide provided higher accuracy, and the relative standard deviation of multiple experiments was less than 10%.
Hydrofluoric acid
Microwave digestion
Relative standard deviation
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