1117: COMPARING RESECTION AND STEREOTACTIC BODY RADIATION THERAPY FOR HCC WITH MACROVASCULA R INVASION
Michael YanZhihao LiPablo Muñoz-SchuffeneggerAnna Theresa SantiagoChristian Tibor Josef MagyarMarco P. A. W. ClaasenNadia RukavinaRoxana Dana BucurIan D. McGilvrayCarol‐Anne MoultonTrevor ReichmanChaya ShwaartzSean P. ClearyGrainne M. O’KaneArndt VogelRobert C. GrantTae Kyoung KimC. NaidooAli HosniRebecca WongAruz MesciJelena LukovicJohn KimGonzalo SapisochinLaura A. Dawson
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Stereotactic radiation therapy
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In this study, we aimed to investigate the interleukin-17A (IL-17A) levels in patients with high-grade glial tumors before receiving radiotherapy, immediately after radiotherapy, and 3 months after radiotherapy.A total of 33 patients who applied to Adana City Training and Research Hospital, Department of Radiation Oncology between December 2016 and May 2018 was included in this study. A total of three blood samples was taken from each patient to assess IL-17A levels before and after radiotherapy and 3 months after the completion of radiotherapy.The differences in IL-17A levels between genders were not statistically significant. IL-17A levels progressively decreased after the radiotherapy and 3 months after the radiotherapy as compared to the levels before radiotherapy. However, this was not statistically significant. IL-17A levels in the non-surviving patients were high before and after radiotherapy as compared to the surviving ones, but this was also not statistically significant.As compared to the period before radiotherapy, IL-17A levels tend to decrease in the period of acute and chronic phases of radiotherapy in all patient groups.
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Tumor treatment is one of the most important fields in medical research.Nowadays,a novel method which is combined gene therapy with radiotherapy plays an important role in the field of cancer research,and mainly includes immune gene therapy combined with radiotherapy,suicide gene therapy or tumor suppressor gene therapy combined with radiotherapy,antiangiogenesis gene therapy combined with radiotherapy and protective gene therapy combined with radiotherapy based on the technical features.This review summarized the current status of combined therapies of gene therapy and radiotherapy and possible mechanism.
Key words:
Tumor; Genetherapy; Radiotherapy
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This chapter contains sections titled: Introduction The great debate: surgery versus radiotherapy Surgery plus adjuvant radiotherapy How does radiotherapy work? Methods of radiotherapy administration Radiotherapy simulation and planning Radiotherapy treatment factors Optimising radiotherapy treatment Treatment-related toxicities Acute radiotherapy toxicities Late radiotherapy toxicities Second malignancies Radiotherapy and quality of life Conclusion Frequently asked questions Resources References
Adjuvant radiotherapy
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Objective:To study on whether radiotherapy affects on T cell subgroups,and to research on the effects of immunoenhancing agents on the immune side effects of radiotherapy.Methods:Sixty-six malignant tumour patients were divided into two groups,radiotherapy alone and radiotherpay plus immunoinhancing agents therapy groups.All patients were subjected to high energy X-rays and electronic rays outer local reginal therapy.T cell subgroups levels were measured before and after the radiotherapy.Results:CD 3,CD 4 and CD 8 decreased significantly after radiotherapy (P0.05) in radiotherapy alone group.There were no differences in CD 3,CD 4 and CD 8 before and after radiotherapy in the group of radiotherapy plus immunoinhancing agents therapy.Conclusions:Radiotherapy may cause the decrease in T cells of all subgroups and immunoinhancing agents may antagonize the side effects of radiotherapy. [
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Objective To analyze the effects between three different therapy materials for non-small cell lung cancer(NSCLC).Methods 327 patients who suffered from NSCLC were treated by radiotherapy alone,radiotherapy after operation,and chemotherapy combined with radiotherapy.Results The 3-and 5-year survival rates of radiotherapy after operation were higher than radiotherapy alone and chemotherapy combined radiotherapy groups; radiotherapy alone higher than chemotherapy combined radiotherapy groups.Conclusions There was on relationship between the survival rate and the pathological classification,but there was a close relationship between the clinical stage and the selecting therapy in survival rate.
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To analyze the effects of radiotherapy and its timing on the survival and safety of patients with newly diagnosed distant metastatic NPC in non-high-incidence areas.We retrospectively analyzed 94 newly diagnosed NPC patients with distant metastatic admitted to our hospital from January 2011 to June 2018. They were divided into three groups: no radiotherapy group received chemotherapy alone, early radiotherapy group was combined with radiotherapy during 1 to 3 cycles of chemotherapy, and late radiotherapy group was combined with radiotherapy after 4-6 cycles of chemotherapy were effective. The efficacy and side effects of the three groups were compared, and the prognostic factors were analyzed.The 6-month, 1-year and 2-year PFS were 53.6%, 14.3% and 3.6% in no radiotherapy group, 71.0%, 38.7% and 19.4% in early radiotherapy group, 88.6%, 48.6% and 22.9% in late radiotherapy group; the radiotherapy groups were better than the no radiotherapy group, and the difference was statistically significant (P < 0.017). The 1-year, 2-year and 3-year OS were 75.0%, 32.1% and 0 in no radiotherapy group, 77.4%, 54.8% and 12.9% in early radiotherapy group, 85.7%, 71.4% and 31.4% in late radiotherapy group; the radiotherapy groups were better than the no radiotherapy group, and the differences were statistically significant (P < 0.017). There was no significant difference in OS and PFS between the two radiotherapy groups. Univariate and multivariate analysis showed that HBV (P = 0.031), number of metastases (P = 0.002), liver metastases (P = 0.038), radiotherapy (P < 0.001) and treatment response (P = 0.011) were related to OS. There was no significant difference in the incidence of adverse events (P > 0.017).Early and late combined radiotherapy had similar clinical efficacy and both prolonged PFS and OS for patients with newly diagnosed distant metastatic NPC in non-high-risk areas. If chemotherapy response is expected to be poor, radiotherapy can be received early.
Univariate analysis
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Objective: To compare efficacy of chemo radiotherapy and single radiotherapy treatment on advanced cervical cancer and its side effects.Methods: A total of 46 cervical cancer cases at II b-IV stage confirmed by pathological analysis were selected and randomly divided into chemo radiotherapy group and radiotherapy group by half.The method and dosage of radiotherapy were the same in two groups.And patients in chemo radiotherapy group also had cisplatin combination chemotherapy for 3 times.every four weeks.Short-term,long-term treatment effects and side effects were observed and compared.Results:The short-term efficacy of chemo radiotherapy group was 95.23%(22/23),significantly higher than 69.20%(16/23) of the radiotherapy alone group(P0.05);3 and 5-year survival rates of chemo radiotherapy group were 86.96% and 65.22%,significant higher than that of the radiotherapy alone group(60.87% and 43.48%)(P0.05);toxicity and radiation adverse reactions of of the radiotherapy alone group was significantly higher than the radiotherapy alone group(P0.05),but after treatment they were tolerable.Conclusions: Synchronous radiochemical therapy have better clinical efficacy than that with radiotherapy alone in treatment of advanced cervical cancer,although with higher toxicity and side effect.But after treatment it can be tolerated,and does not affect the efficacy.
Chemo-radiotherapy
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