Fibrocyte: A missing piece in the pathogenesis of fibrous epulis

This report contains a statistical study of 874 cases of epulis diagnosed by the Department of Pathology of Tokyo Dental College from 1966 to 1986. 1. Of the 874 cases, 344 were epulis fibrosa, 217 were epulis granulomatosa, 78 were epulis fibromatosa, 74 were epulis fibrosaosteoplastica, 51 were epulis hemangiomatosa, 43 were epulis fibrosa teleangiectaticum, 15 were epulis cementoplastica, 14 were epulis osteomatosa, 3 were congenital epulis, 2 were giant cell epulis, and 1 was epulis cementomatosa. 2. As has been reported in other literature, there is a marked tendency for this condition to occur in females (331 male cases and 539 female cases). 3. Our data indicate a higher occurrence rate in people in their fifties, although the occurrence rates were similar in people in their twenties and in people in their sixties. 4. The epulis was observed most frequently in the maxillary incisor region.

Epulis

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Light microscopic and electron microscopic observation of idiopathic nonspecific interstitial pneumonia

Yun Zhang

Objective:To observe the microscopic and ultrastructural features of idiopathic nonspecific interstitied pneumonia(INSIP) and its relation with pulmonary interstitial fibrosis. Methods:Samples of lung biopsy tissue of seven cases with INSIP taken by video-assisted thoracoscope were observed under the light microscope(LM) and electron miscroscope(EM).Results:The histologic features of INSIP were varying degrees of pulmonary interstitial imflammation and fibrosis, and prominently infiltrated with lymphocytes and plasma cells. The ultrastructural features of INSIP showed hyperplasia of typeⅡpneumocytes, with proliferation of fibrocytes, deposition of collagenous fibers, and infiltration of lymphoctytes, plasma cells and macrophages in the alveolar septa. Mast cells degranulated could be seen frequantly. In the firbrosing pattern of INSIP, prominent hyperplasia of smooth muscles and myofibroblasts occurred. Conclusions:The hyperplasia of the mature fibrocytes was the main feague of the interstitial fibrosis of INSIP. Multi-cellular element may be associated with the processes.

Fibrocyte

Myofibroblast

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Decision letter for "Fibrocyte: A missing piece in the pathogenesis of fibrous epulis"

Fibrocyte

Epulis

Pathogenesis

10.1111/odi.14847/v1/decision1

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