Modeling and Simulation of a Bio-Inspired Nanorobotic Drug Delivery System
0
Citation
24
Reference
10
Related Paper
Abstract:
Current targeted drug delivery systems like passive targeting or active targeting are still inefficient because they mainly depend on blood circulation and extravasation. It is significant that drug delivery carriers are capable of autonomously swimming towards target site (e.g., diseased cells or tumors) and releasing drugs. In recent years, targeted drug delivery depending on autonomous swimmers such as nanorobot has been actively studied and a number of solutions have been proposed. In the paper, we propose a nanorobot-based system comprising of nanorobot behavior planning algorithm, drug reception model and adjusting method of release rate for a simulation of local targeted drug delivery. In this system, nanorobots can move and accumulate at target site by simulating bacterial chemotaxis, and determine the timing of drug release relying on quorum sensing. In addition, nanorobots can dynamically adjust the rate of drug release depending on the concentration of tumor biomarker. A simulation environment is established in order to evaluate the nanorobotic drug delivery system. The simulation results show that the nanorobotic drug delivery system can not only deliver drugs effectively at desired location but also enhance efficiency of drug utilization.Keywords:
Nanorobotics
Targeted drug delivery
Extravasation
Nanorobotics
Cite
Citations (2)
Application of nanotechnology in medicine has improvised diagnosis, treatment, and control of biological systems. Nano technological approach to particle design has made possible the availability of a wide spectrum of Nanoscale drugs and devices, which are now collectively referred as 'Nanomedicines'.
There has been tremendous amount of research going on in the field of Nanomedicine. This has resulted into several smart nanomaterials offering interesting applications in tissue engineering, nanorobotics for drug delivery, treatment and detection of cancer, theraupetic use in cardiovascular system, pain therapy, etc.
Nanomedicine has shown many promising prospects and thus has gained a huge global reception over the past decade. It has been proved to be the most potent tool to resolve almost all human health issues.
This review paper is intended to create awareness for the advances in the field of Nanomedicine and highlight few concerns regarding its applications.
Nanorobotics
Cite
Citations (2)
Nanorobotics
Cite
Citations (0)
Nanorobotics
Cite
Citations (0)
Nanorobotics
Cite
Citations (406)
This chapter discusses nanotechnology as it applies to medicine, including different types of nanorobots and some of the challenges inherent to building robots on the nanoscale. It focuses on a number of different nanostructures one can use to detect the presence of cancer or other diseases in the body. The chapter describes the problems with current cancer treatments, as well as methods such as nanoparticle heating method, magnetic manipulation, that can be used to treat disease at the cellular level within the body. It addresses possible effects of nanorobots on the body and factors that determine biocompatibility on the nanoscale. The chapter also describes recent progress in wireless power and how this idea can be directly applied to nanomedicine. It explores some of the specifics of nanomedical research for cancer and also discusses the organizations, centers, universities, and scientists actually doing the research as of the fall of 2014.
Nanorobotics
Cite
Citations (2)
Current targeted drug delivery systems like passive targeting or active targeting are still inefficient because they mainly depend on blood circulation and extravasation. It is significant that drug delivery carriers are capable of autonomously swimming towards target site (e.g., diseased cells or tumors) and releasing drugs. In recent years, targeted drug delivery depending on autonomous swimmers such as nanorobot has been actively studied and a number of solutions have been proposed. In the paper, we propose a nanorobot-based system comprising of nanorobot behavior planning algorithm, drug reception model and adjusting method of release rate for a simulation of local targeted drug delivery. In this system, nanorobots can move and accumulate at target site by simulating bacterial chemotaxis, and determine the timing of drug release relying on quorum sensing. In addition, nanorobots can dynamically adjust the rate of drug release depending on the concentration of tumor biomarker. A simulation environment is established in order to evaluate the nanorobotic drug delivery system. The simulation results show that the nanorobotic drug delivery system can not only deliver drugs effectively at desired location but also enhance efficiency of drug utilization.
Nanorobotics
Targeted drug delivery
Extravasation
Cite
Citations (0)
Abstract: The human body comprises molecules; hence, the availability of molecular nanotechnology will permit dramatic progress to address medical problems and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine could develop devices that are able to work inside the human body in order to identify the early presence of a disease, and to identify and quantify toxic molecules and tumor cells, for example. Nanodentistry will make possible the maintenance of comprehensive oral health by employing nanomaterials, including tissue engineering and, ultimately, dental nanorobots. This review is an attempt to highlight the possible applications of nanotechnology and the use of nanomaterials in dentistry. Keywords: nanotechnology, molecule, nanomedicine, nanodentistry, nanorobots
Nanorobotics
Applications of nanotechnology
Cite
Citations (131)
Nanorobotics
Cite
Citations (6)
As nanotechnology develops in the fields of mechanical engineering, electrical engineering, information and communication, and medical care, it has shown great promises. In recent years, medical nanorobots have made significant progress in terms of the selection of materials, fabrication methods, driving force sources, and clinical applications, such as nanomedicine. It involves bypassing biological tissues and delivering drugs directly to lesions and target cells using nanorobots, thus increasing concentration. It has also proved useful for monitoring disease progression, complementary diagnosis, and minimally invasive surgery. Also, we examine the development of nanomedicine and its applications in medicine, focusing on the use of nanomedicine in the treatment of various major diseases, including how they are generalized and how they are modified. The purpose of this review is to provide a summary and discussion of current research for the future development in nanomedicine.
Nanorobotics
Cite
Citations (13)