Author response for "Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps"
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Adenomatous polyps
Value (mathematics)
Objective: To examine the possible role of adenomatous polyps in colorectal cancer development, this study focused on the relationship of the distribution between adenomatous polyps and cancer in the colorectum. Methods: The distribution of 753 adenomatous polyps was compared with that of 35 colorectal cancer lesions in 510 male patients ranging from 45 to 55 yr of age who underwent a total colonoscopy. Results: The incidence of cancer significantly increased with a distal shift in the colorectal sites in comparison with that of adenomatous polyps (p< 0.02). Conclusion: The different distribution between adenomatous polyps and cancer thus suggested that adenomatous polyps at various colorectal sites appear to have a different malignant potential for cancer development.
Adenomatous polyps
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Screening for cancer is performed in order to detect unsuspected cancers in an asymptomatic population. Screening is justified for the detection of precancer and cancer when the screening test is safe and the disease has a prevalence that justifies the cost and also when testing has low rates of false positive results. Screening can lead to the early diagnosis of specific cancers which, when treated, can result in a prolonged life span. Colorectal cancer is the third-most common form of cancer in the Western world. Many of these cancers are thought to arise from precancerous lesions in the colon, such as adenomatous polyps. The specific advantage of colorectal cancer screening include the earlier detection of such cancers, the detection of benign conditions such as polyps that can predispose to cancer and the potential for earlier and curative therapy in these patients. Screening for colorectal cancer is indicated where life expectantly is greater then five years and, in general, for people under 75 years of age.
Adenomatous polyps
Screening test
Cancer screening
Sigmoidoscopy
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Colorectal Surgery
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Analysis of the Risk Factors of Postoperative Recurrence for Elderly Patients with Colorectal Cancer
Objective Our retrospective study was aimed to analyzed the risk factors of postoperative recurrence for elderly patients with colorectal cancer. Methods Clinical data of colorectal cancer patients received surgery treatment at our hospital from 2003 to 2008 was retrospectively analyzed. Results A total of 325 patients were analyzed,the rate of postoperative recurrence was 25. 23%( 82 /325). Cox regression analysis showed that T3-T4 perioperative( P = 0. 015),blood transfusion( P =0. 032),lymph node metastasis( P = 0. 018) and blood vessel invasion( P = 0. 026) were the independent risk factors of recurrence after surgery treatment in five years for elderly patients with colorectal cancer. Conclusion Recurrence of high-risk groups of follow-up work was expected to early detection of recurrence and timely intervention.
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Objective Study of elderly patients with obstructive colorectal cancer surgical treatment.Methods 60 cases of surgical operation treatment of intestinal obstruction in patients with colorectal cancer.A retrospective analysis of clinical data.Results In this group,the observation group of 5 cases of postoperative complication,accounted for 16.67%;the control group of 4 cases,accounting for 13.33%.Hospital mortality in 4 cases(6.67%),2 cases of death in emergency operation,selective operation in 2 cases.Conclusion Active peri operation period the preparation,choose appropriate operation,senile obstructive colorectal patients postoperative recovery rate.
Surgical operation
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Objective:To explore the surgical treatment effect on elderly patients with colorectal cancer complicated by acute intestinal obstruction.Methods:The clinical cases of 56 patients with colorectal cancer complicated by acute intestinal obstruction,in which 41 elderly patients were analyzed according to the disease diagnosis and emergency treatment.Results:All the right colon cancer patients conductedⅠresection and anastomosis with few complications.Reasonable choice of surgery was made according to the patients' general condition and the severity to left colon cancer patients.
Emergency Surgery
Intestinal Cancer
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Objective To investigate the clinical effects of surgical operation on colorectal cancer complicated by bowel obstruction. Methods Treatment methods and clinical efficacies were analyzed in 42 patients with colorectal cancer and bowel obstruction. Results Standardized surgical procedures were successfully completed in all patients. Average intraoperative blood loss and mean operating time were(172.4 ±22.2)mL and(148.5 ±16.0)min, respectively. The total effective rate was 64.3%. The incidence of complications was 7.1%(1 case of incision infection and 1 case of cardiovascular disease). No patients died during 3 months of follow-up. The serum levels of carcinoembryonic antigen and carbohydrate antigen CA19-9 gradually decreased over time(P0.05).Conclusion Appropriate surgical approach should be selected according to the patient's condition to improve curative efficacies, reduce complications and increase survival in patients with colorectal cancer and bowel obstruction.
Carcinoembryonic antigen
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Inflammatory response
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Colorectal carcinoma is a common cancer in the Western world. It vies to be the second leading cause of cancer deaths in the United States and affects both men and women equally. This cancer arises from many interactions that involve hereditary and environmental influences (). Colorectal cancer does not develop abruptly de novo, but progresses through a series of anatomical and physiological changes (). Thus, early in this process, changes in epithelial cell proliferation and differentiation occur while the mucosa appears grossly normal; this is followed by the development of aberrant crypt foci, adenomatous polyps, cancer in polyps, and then frank carcinoma (). The process of a normal epithelium changing to an adenoma and cancer takes a considerable amount of time, probably 5–10 yr for adenoma formation and perhaps another 10 yr for the development of cancer.
Adenomatous polyps
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