A systematic Review on Green Synthesis of Silver Nanoparticles Using Plants Extract and Their Bio-medical Applications
Mst Sanjida AkhterMd. Ataur RahmanRezaul Karim RiponMahfuza MubarakMahmuda AkterShamim MahbubFiroj Al‐MamunMd. Tajuddin Sikder
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Abstract:
Nanoparticles have recently become considered as a crucial player in contemporary medicine, with therapeutic uses ranging from contrast agents in imaging to carriers for the transport of drugs and genes into a specific target. Nanoparticles have the ability to have more precise molecular interactions with the human body in order to target specific cells and tissues with minimal adverse effects and maximal therapeutic outcomes. With the least number of side effects and the greatest possible therapeutic benefit, nanoparticles can target particular cells and tissues through more precise molecular interactions with the human body. The majority of global public health problems are now treated with green synthesized silver nanoparticles (AgNPs), which substantially affect the fundamental structure of DNA and proteins and thus display their antimicrobial action. AgNPs can inhibit the proliferation of tumor cells and induce oxidative stress. By inhibiting vascular endothelial growth factor (HIF)-1, pro-inflammatory mediators generated by silver nanoparticles are reduced, mucin hypersecretion is lessened, and gene activity is subsequently regulated to prevent infections. The biogenic synthesis of silver nanoparticles (AgNPs) using various plants and their applications in antibacterial, antifungal, antioxidant, anticancer, anti-inflammatory, and antidiabetic activities have been extensively discussed in this article. Also, because only natural substances are utilized in the manufacturing process, the particles that are created naturally are coated, stabilized, and play a vital role in these biomedical actions. The characterization of AgNPs, possibility of preparing AgNPSs with different shapes using biological method and their impact on functions and toxicities, impact of size, shape and other properties on AgNPs functions and toxicity profiles, limitations, and future prospects of green-mediated AgNPs have also been reported in this study. The major goal of this study is to provide readers with a comprehensive, informed, and up-to-date summary of the various AgNPs production and characterization methods and their under-investigational antioxidant, antibacterial, and anticancer, antidiabetic, antifungal and anti-inflammatory properties. This review provides instructions and suggestions for additional studies based on AgNPs. This evaluation also pushes researchers to look into natural resources like plant parts in order to create useful nanobiotechnology.Keywords:
Silver nanoparticle
[Objective] The study was to explore whether antimicrobial activity of the antimicrobial peptides extracted from immunized Tenebrio molitor varied with different pathogens as inducers.[Method]By inducing T.molitor hungry larvaes to generate immune response via feeding with bacteria and with fungi or actinomycete post to pricking,the antimicrobial peptides extracts were obtained by grinding and centrifuging the cultures.Its antimicrobial activity against 26 pathogens was measured by bacteriostatic ring,and evaluated by trisection to four types and inhibitory spectrum.[Result]Both the antimicrobial activity and antimicrobial spectrum of the antimicrobial peptides extracts varied remarkably among different pathogens as inducers.[Conclusion]Bio-control used strains have obvious advantage in inducing the insect to express body fluid immunity material-antimicrobial peptides.
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To obtain strong activity antimicrobial agent,the antimicrobial properties of Gemini antimicrobial agents(C1,C2,C3 and C4) were evaluated by quantifying the minimal inhibitory concentration(MIC),n-dodecyl-trimethylammonium bromide(DTAB) as a comparison.The results indicated that these Gemini antimicrobial agents against S.aurueus,E.coli and C.albicans were superior to DTAB.The MIC of C2 against S.aurueus and E.coli were 1.5 μg·L-1 and 3.91 μg·L-1,respectively.The MIC of C4 against C.albicans was 3.91 μg·L-1.these Gemini antimicrobial agents exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as yeast.Their antimicrobial properties rely on the Gemini molecular structures with longer length of main-chain,full-chain and R groups,their antimicrobial activities are stronger,and fluorinated alkyl groups can markedly improve their antimicrobial properties compared with the same hydrocarbon one.
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Mushrooms have an acclaimed history of therapeutic use in traditional medicine. The prevalent occurrence of infectious diseases is becoming a worldwide problem, due to bacterial resistance against antimicrobial drugs which have been long used for therapeutic and prophylactic purposes. For this reason, the search has intensified for natural sources with antimicrobial activity. The literature contains scientific data about the high antimicrobial activity of mushrooms against Gram-positive and Gram-negative bacterial species. In this review we have focused on compounds obtained from mushrooms which exhibit antimicrobial activity, commonly used methods for evaluation of antimicrobial activity and last but not least on syntheses of some selected compounds originally isolated from mushrooms. Keywords: Mushrooms, extracts, antimicrobial activity, synthesis, MIC.
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Objective To evaluate the antimicrobial agents usage in a hospital. Methods Forty patients’ medical records were selected for retrospective analysis, patients were discharged in the year of 1998 and 2000 respectively. Results In 1998, antimicrobial resistant rate was higher, 96.25% of patients received antimicrobial agents, antimicrobial cost accounted for 52.38% of the total hospitalization expense; most antimicrobial agents were for treatment, the majority of patients received two kinds of antimicrobial agents simultaneously; in 2002, 93.54% of patients received antimicrobial agents, antimicrobial cost accounted for 50.47% , most antimicrobial agents were for treatment, and majority of patients only received one kind of antimicrobial drugs. There was significant difference in the total usage rate of antimicrobial agents between two surveys. Conclusion Target surveillance on antimicrobial agents usage should be carried out to reduce the overuse of antimicrobial agents and decrease the bacterial resistance.
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[Objective] The study was to explore whether antimicrobial activity of the antimicrobial peptides extracted from immunized Tenebrio molitor vary with different pathogens as inducers.[Method] By inducing hungry T.molitor larvaes to generate immune response via feeding with bacteria and with fungi or actinomycete after pricking,the antimicrobial peptide extract was obtained by grinding and centrifuging the cultures.Its antimicrobial activity against 26 pathogens was measured by bacteriostatic ring,and evaluated by trisection to four types and inhibitory spectrum.[Result] Both the antimicrobial activity and antimicrobial spectrum of the antimicrobial peptide extract varied remarkably among different pathogens as inducers.[Conclusion] Bio-control used strains have obvious advantage in inducing the insect to express body fluid immunity material-antimicrobial peptides.
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Diphenyl ether
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Gram-Positive Bacteria
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