Glomangioma.
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Abstract:
A 22-year-old man presented with a 9-year history of multiple blue nodules on the medial aspect of his right arm. A biopsy specimen showed a cystic space with a cuboidal cellular lining that stained positive for α-smooth-muscle actin; these findings were consistent with multiple glomangiomas. We review the clinical and histopathologic characteristics of this rare entity.Keywords:
Clinical history
Cuboidal Cell
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Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals. It is typically a slow‐growing, flesh‐ to reddish‐colored nodule or plaque. Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells. The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts. The co‐existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma. The differential diagnosis includes poroma, porocarcinoma, fibroepithelioma of Pinkus and clear cell acanthoma. ESFA stain positively with epithelial membrane antigen and carcinoembryonic antigen. Cytokeratin studies have been inconsistent.
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Carcinoembryonic antigen
Columnar Cell
Nodule (geology)
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Focal scarring has been observed in two patients in a second biopsy of the same kidney. It has been attributed to the trauma of the initial puncture, especially to the late effects of vascular spasm and disruption in a zone surrounding the needle track. To prevent confusion in histologic interpretation, the contralateral kidney should be used for a second biopsy.
Confusion
Percutaneous biopsy
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Objective To investigate clinicopathologic features and immunophenotype of sclerosing hemangioma of lung(SHL).Methods Twenty cases of SHL were studied by pathologic histology and immunohistochemistry.Results SHL has a characteristic architecture composed of round stromal cells and surface cuboidal cells. It has four histopathologic pattern that contain soild pattern,papillary pattern,hemorrhagic pattern and sclerotic pattern. Immunohistochemically these two kind's of cells were both positive for TTF-1 and EMA,and only surface cuboidal cells were positive for AE1/AE3 and SP-B.Conclusion SHL is a tumor that orginates from the epithelial cell of primary respiratory tract. Both the round stromal cells and surface cuboidal cells are neoplastic. Morphology and immunophenotype of SHL acts an important role in diagnosis and differential diagnosis.
Cuboidal Cell
Immunophenotyping
Histology
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Nuclear Medicine The Children's Hospital Westmead, Sydney Nuclear Medicine and Diagnostic Ultrasound RPAH Medical Centre Newtown, NSW University of Sydney NSW, Australia [email protected] Nuclear Medicine and Diagnostic Ultrasound RPAH Medical Centre Newtown University of Sydney NSW, Australia Melanoma Institute Australia Sydney University of Sydney NSW, Australia Disclosure: John Thompson has worked as a consultant for GlaxoSmithKine, Provectus, and Roche. The authors declare no conflicts of interest.
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Tumors with clinically recognizable mucin production arising from bile duct, "mucin-producing bile duct tumors (MPBTs)," have not been studied yet for their pathologic features and classification in details. The clinical findings of MPBT have a lot of similarities to those of pancreatic intraductal papillary-mucinous neoplasm. In the present study, we examined 30 MPBTs and classified them into two distinct morphologic categories: 22 cases of "columnar type" composed of pseudostratified columnar cells with basophilic cytoplasm and columnar nuclei and 8 cases of "cuboidal type" composed of pancreaticobiliary and/or oncocytic pattern. Pancreaticobiliary pattern showed abundantly branched papillae lined by acidophilic cuboidal cells with round nuclei, whereas oncocytic pattern was characterized by intraepithelial lumina and cribriform pattern composed of abundant oxyphilic cells with round nuclei, and these patterns overlapped frequently. There were significant differences in the clinicopathologic findings including macroscopic findings, morphometric data, mucin expression profiles (MUC2 expression in columnar type and MUC6 expression in cuboidal type), and cell proliferative activities between columnar type and cuboidal type. Patients with columnar type showed significantly poorer survival than those with cuboidal type. We concluded that columnar type and cuboidal type of MBPTs belong to different lineage of neoplasm and that they are counterparts of "intestinal type" and "pancreaticobiliary type" of pancreatic intraductal papillary-mucinous neoplasm, respectively.
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Basophilic
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징거미새우의 수정관은 정소의 중앙 후반부에서 기원되어 제 5보각의 기부에 위치한 생식공까지 연결되어 있고 그 형태에 따라 짧고 가느다란 기부, 나선부, 직선상의 말단부 그리고 사정관 4부분으로 구분할 수 있다. 수정관 기부의 내강은 높이가 $12{\~}28{\mu}m$ 의 SCE가 랴은 기저막으로 둘러싸여 있다. 그리고 일부에 높은 HCE도 관찰된다. 나선부와 말단부의 내강은 배면으로는 $40\~120{\mu}m$ 높이의 높은 HCE가 그리고 복면과 측면에는 $12\~28{\mu}m$ 범위의 SCE로 구성되어 있다. 수정관의 사정관에는 종주근과 환상근으로 이루어진 근세포들로 둘러싸여 있고 2종류의 상피세포는 거의 비슷한 비율로 이루어져 있다. 한편, 기부의 내강에는 성숙정자와 호염기성 기질만 관찰되는 반면, 나선부부터는 SCE주변으로 호 산성 기질이 함께 나타난다. 사정관내에 저장되어 있던 정자덩어리와 정자를 싸고있는 물질이 양쪽의 생식공으로부터 한 쌍의 관형태의 정포로 되어 교미 직후의 암컷의 $2\~4 $ 또는 5번째 보각의 복판에 부착된다. 정포는 그 길이가 $2.7\~4.0mm$ , 폭이 $1.5\~2.7mrn$ 정도의 크기였다. Vas deferens is a long tube and could be divided into four regions as its morphological characters: a short and slender proximal region, a convoluted region, a straight and more thick distal region, and an ejaculatory duct, It is connected with the posterior outer horns of the testis and runs to the gonopores opened on the coxa of the fifth walking legs, The proximal region consists almost entirely of simple cuboidal epithelial cells, $12\~28{\mu}$ m in height, surrounded by a thin basal membrane. A small aggregation of high cuboidal epithelium is obsened from one side of the proximal region. The convoluted and distal region is composed of two kinds of epithelial cells; high cuboidal epithelial cells, $40\~120{\mu}m$ in height located in dorsal portion and simple cuboidal epithelial cells of $12\~28{\mu}$ m in height located in ventral and lateral portion. The ejaculatory duct is surrounded with two kinds of muscle layers, inner longitudinal and outer circular muscle fibers, The lumen is lined with high and simple cuboidal epithelium in almost equal proportions. The proximal region contains mature sperm and basophilic substances. The eosinophilic substances appeared newly going toward the convoluted region and are laid along simple cuboidal epithelial cell layer. Tube-like content (spermatophore) of the vas deferens is ejaculated from a pair of genital pores at mating. Two masses of the content fuse together side by side and are usually deposited on the female thorax between the second and fourth or fifth pereiopods, The spermatophore formed measures $2.7\~4.0$ mm in length and $1.5\~2.7$ mm in width.
Cuboidal Cell
Vas deferens
Ejaculatory duct
Columnar Cell
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Objective To describe the clinicopathologic features and characteristics of pulmonary sclerosing hemangioma( PSH).Methods Clinical data,imaging material and pathologic changes were analyzed in 14 patients with PSH. These cases were studied by HE stain and immunohistochemieal stains. Results PSH was histologically composed of a mixture of papillary,solid,sclerotic or hemorrphagic patterns. There were two types of tumor cells: cuboidal cells and polygonal cells. Immunohistochemical staining revealed that the cuboidal cells expressed TTF-1,CKpan and EMA,and the polygonal cells expressed TTF-1,vimentin and EMA. A few cases expressed Syn,CgA,CD56,ER and PR weakly. None of the cuboidal cells and polygonal cells expressed mesothelium,CD31 and CD34. Conclusion PSH is a rare benign tumor particularly prevalent in middle-aged women. Histopathology of PSH is various. Immunohistochemical stains are the main approaches for the diagnosis and differential diagnosis.
Cuboidal Cell
Histopathology
CD31
Stain
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