Identification, Phylogeny and Expressional Profiles of Peptidoglycan Recognition Protein (PGRP) Gene Family in Sinonovacula constricta

PirAB is a binary protein complex secreted by specific strains of Vibrio parahaemolyticus (Vp) that harbor the pVA1 virulence plasmid and express PirAVp and PirBVp toxins. PirABVp causes acute hepatopancreatic necrosis disease (AHPND), a newly emergent penaeid shrimp disease that can cause 70–100% mortality and has resulted in great economic losses since its appearance. The cy-totoxic effect of PirABVp on the epithelial cell of the shrimp hepatopancreas has been extensively reported. Our studies found that the PirBVp subunit has lectin activity and recognizes mucin-like O-glycosidic structures in the shrimp hepatopancreas. The PirAVp subunit may have a stabiliza-tion function of the binary complex. However, we also found that Vp AHPND changes the water microbiota community structure and causes a significant reduction in several bacteria, especially Neptuniibacter spp. We propose that the PirABvp toxin could exhibit a dual role: damage the shrimp hepatopancreas and kill surrounding bacteria.

Hepatopancreas

Penaeus

Pore-forming toxin

Vibrio harveyi

Penaeidae

10.20944/preprints202201.0200.v1

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Function of a novel C-type lectin with two CRD domains from Macrobrachium rosenbergii in innate immunity

Developmental & Comparative Immunology (2014)

Xin Huang Ying Huang Yanru Shi Qian Ren Wen Wang

Macrobrachium rosenbergii

C-type lectin

White spot syndrome

Hepatopancreas

10.1016/j.dci.2014.11.015

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HcCUB-Lec, a newly identified C-type lectin that contains a distinct CUB domain and participates in the immune defense of the triangle sail mussel Hyriopsis cumingii

Developmental & Comparative Immunology (2018)

Ying Huang Qian Ren

C-type lectin

Lipoteichoic acid

10.1016/j.dci.2018.12.012

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Function of two ficolin-like proteins in innate immune defense of the oriental river prawn, Macrobrachium nipponense

Fish & Shellfish Immunology (2017)

Tingting Li Lei Wu Min Jin Futong Ma Xin Huang

Ficolin

Macrobrachium rosenbergii

Hemolymph

Prophenoloxidase

10.1016/j.fsi.2017.07.059

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Peptidoglycan recognition proteins in insect immunity

Molecular Immunology (2018)

Qiang Wang Meijia Ren Xiaoyong Liu Hengchuan Xia Keping Chen

Pathogen-associated molecular pattern

10.1016/j.molimm.2018.12.021

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Novel fibrinogen-related protein with single FReD contributes to the innate immunity of Macrobrachium rosenbergii

Fish & Shellfish Immunology (2018)

Keke Han Xuefeng Chen Lei Wu Zhuoxing Zhang Futong Ma

Macrobrachium rosenbergii

White spot syndrome

Hepatopancreas

Litopenaeus

10.1016/j.fsi.2018.08.036

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Citations (15)

Progress on Peptidoglycan Recognition Proteins in Innate Immune System

Progress in Veterinary Medicine (2014)

Xu Guang Xi

The innate immune system is a primitive mechanism,which exists commonly in vertebrates and invertebrates and is responsible for defending against invading microorganisms.Peptidoglycan recognition proteins(PGRPs)are pattern recognition receptors(PRRs)that recognize bacteria and their unique cell wall component,peptidoglycan(PGN),so they play an important role in recognizing and regulating in the innate immunity.The research of PGRPs is important to understand the response mechanism of the innate immune system.This paper reviewed the recent progress on the peptidoglycan recognition proteins(PGRPs)including structure,functions,signal pathway and its interaction with peptidoglycan in innate immune system.

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Molecular cloning and functional characterization of a short peptidoglycan recognition protein from triangle-shell pearl mussel (Hyriopsis cumingii)

Fish & Shellfish Immunology (2018)

Ying Huang Jianlin Pan Xuguang Li Qian Ren Zhe Zhao

Scylla paramamosain

Hepatopancreas

10.1016/j.fsi.2018.12.007

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Citations (16)