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    Author Correction: Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans
    Scientific Reports (2022)
    Fanny M. ElahiDanielle HarveyMarie AltendahlNivetha BrathabanNicole FernandesKaitlin B. CasalettoAdam M. StaffaroniPauline MaillardJason D. HinmanBruce L. MillerCharles DeCarliJoel H. KramerEdward J. Goetzl
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    Keywords:
    Mediator
    Complement
    Inflammatory mediator
    Brain Function
    Topics:
    Inflammation biomarkers and pathways
    Extracellular vesicles in disease
    Atherosclerosis and Cardiovascular Diseases
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    [Leukotrienes promote inflammation and proliferation. Interaction with other mediator systems--modulation by therapeutic measures].
    PubMed (1998)
    Claudio Denzlinger
    Mediator
    Inflammatory mediator
    Modulation (music)
    Citations (0)
    Cellular and Mediator Mechanisms of Allergic Inflammation
    Allergy (2006)
    J.J. Prochnau
    Mediator
    Inflammatory mediator
    Allergic Inflammation
    Citations (1)
    Variability of inflammatory mediator production by human periodontal fibroblasts stimulated with bacterial lipopolysaccharide
    In Vitro Cellular & Developmental Biology - Animal (1996)
    Sreenivas KokaRichard ReinhardtConstance R. MazeJohn K. Dyer
    Mediator
    Inflammatory mediator
    Citations (4)
    Inflammatory Mediators and Intestinal Injury
    Clinics in Perinatology (1994)
    Michael S. CaplanWilliam MacKendrick
    Mediator
    Platelet-activating factor
    Necrotizing Enterocolitis
    Inflammatory mediator
    Pathophysiology
    Citations (86)
    Differential Mechanisms of Inflammatory Mediator-Induced Epithelial Apoptosis
    Pediatric Research (1999)
    Tamás JillingLuba AdlerDan LiMichael S. Caplan
    Mediator
    Inflammatory mediator
    Citations (0)
    Role of P2X7 receptor in release of IL-1β, possible mediator of pulmonary inflammation
    H. Shafie
    Mediator
    Inflammatory mediator
    Citations (0)
    IL-18 is a primary mediator of inflammation associated with DSS-induced colitis: Blocking IL-18 prevents intestinal damage
    Gastroenterology (2001)
    Pallavur V. SivakumarGina WestrichSuzanne T. KanalyJohn E. SimsJonathan M.J. Derry
    Mediator
    Blocking (statistics)
    Primary (astronomy)
    Inflammatory mediator
    Citations (2)
    ESDR198 - Il-33 is a central mediator of necroptosis-induced skin inflammation.
    Marion Bonnet
    Mediator
    Inflammatory mediator
    Citations (0)
    ESE-1 Is a Novel Transcriptional Mediator of Inflammation That Interacts with NF-κB to Regulate the Inducible Nitric-oxide Synthase Gene
    Journal of Biological Chemistry (2001)
    Susan A. RuddersJohn GasparRebecca MadoreCarole VolandFranck Grall
    Inflammation is a hallmark of several vascular diseases. The nuclear factor κB (NF-κB) transcription factors are dimeric proteins involved in the activation of a large number of genes in response to inflammatory stimuli. We report the involvement of a novel member of the ETS transcription factor, ESE-1, in mediating vascular inflammation. ESE-1 is induced in response to inflammatory cytokines and lipopolysaccharide in vascular smooth muscle cells, endothelial cells, and cells of the monocyte-macrophage lineage. This induction occurs within hours of stimulation and is mediated by NF-κB transactivation of the ESE-1 promoter. We have identified the inducible form of nitric-oxide synthase (NOS2) as a putative target for ESE-1. ESE-1 can bind to the p50 subunit of NF-κB, and cotransfection of ESE-1 with the p50 and p65 subunits of NF-κB synergistically enhances transactivation of theNOS2 promoter by ESE-1. An ESE-1-binding site within theNOS2 promoter has been identified, the site-directed mutagenesis of which completely abolishes the ability of ESE-1 to transactivate the NOS2 promoter. Finally, in a mouse model of endotoxemia, associated with acute vascular inflammation, ESE-1 is strongly expressed in vascular endothelium and smooth muscle cells. In summary, ESE-1 represents a novel mediator of vascular inflammation.
    Mediator
    Proinflammatory cytokine
    Citations (95)
    Interactions Between Eicosanoids and Other Mediators of Inflammation
    Springer eBooks (1988)
    Paul G. HellewellT.J. Williams
    Mediator
    Inflammatory mediator
    Stimulus (psychology)
    Inflammatory response
    Vascular permeability
    Citations (3)