N-acetylcysteine alleviates pulmonary inflammatory response during benzo[a]pyrene-evoked acute lung injury
Hui ZhaoLin FuHui-Xian XiangYing XiangMeng‐Die LiBian-Bian LvZhu-Xia TanLan GaoCheng ZhangDe‐Xiang Xu
21
Citation
55
Reference
10
Related Paper
Citation Trend
Keywords:
Cellular infiltration
Infiltration (HVAC)
N-acetylcysteine,a precursor of glutathione in cells,is a thiol antioxidant.This article mainly reviewed its recent progress in mechanism of action and its applications in liver diseases including paracetamol-induced toxicosis,severe hepatitis and hepatic failure,anti-HBV and so on,which showed that N-acetylcysteine is medicament with wide application potential.
Mechanism of Action
Thiol
Cite
Citations (0)
AIM: To investigate the key molecular mechanism of inflammatory response in alveolar epithelial cells induced by nontypeable haemophilus influenzae(NTHi).METHODS: A549 cells were co-cultured with NTHi(multiplicity of infection,MOI: 10) and harvested 15 min and 30 min after stimulation.The phosphorylation of p38 mitogen activated protein kinase(p38 MAPK) in A549 cells was detected by Western blotting.The intracellular expression of nuclear factor-κB(NF-κB) p65 was examined by flow cytometry 4 h after stimulation.A549 cells were preincubated with p38 inhibitor(SB203580) or NF-κB inhibitor(PDTC) for 1 h and then stimulated with NTHi for 24 h.The level of interleukin 8(IL-8) in the supernatants was determined by enzyme-linked immunosorbent assay(ELISA).RESULTS: The phosphorylation of p38 MAPK was rapidly induced by NTHi stimulation.The expression of NF-κB p65 in A549 cells after NTHi stimulation was significantly up-regulated compared with control group(P0.05).The level of IL-8 in the supernatants was increased 24 h after bacterial stimulation compared with control group(P0.05).Blockage of p38 MAPK or NF-κB remarkably decreased IL-8 secretion in A549 cells(P0.05).CONCLUSION: NTHi induces inflammatory response in alveolar epithelial cells in a p38 MAPK and NF-κB dependent manner.
Interleukin 8
Cite
Citations (0)
"Authors' reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions." Clinical Toxicology, 60(5), pp. 663–664
Acetaminophen
acetaminophen overdose
Cite
Citations (0)
A short-cut review was carried out to establish whether oral N-acetylcysteine is as effective as intravenous N-acetylcysteine in the management of paracetamol overdose. Seven studies were directly relevant to the question. The author, year and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. The clinical bottom line is that oral N-acetylcysteine is a safe alternative in patients for whom the intravenous route is not an option.
Intravenous Use
Study Type
Cite
Citations (3)
Antidote
Cite
Citations (3)
瞄准：为了是学习 N-acetylcysteine (NAC ) 的角色，在 rifampicin (RMP ) 的一个保护的代理人导致了小老鼠的氧化肝的损害。方法：肝的损害被为 3 wk 给 RMP 的 50 mg/kg 体重生产。NAC (100 mg/kg 体重) 的剂量 intraperitoneally 与 RMP 在联合被给。类脂化合物的分析与体重，肝重量和组织学的观察一起在肝每氧化，巯基层次，细胞色素 P450，超级氧化物歧化酶(草皮) ，过氧化氢酶，谷胱甘肽过氧化物酶，还原酶和转移酶被估计。结果：当抗氧化的酶被改变时， RMP 暴露在身体和肝重量导致了没有变化但是非，蛋白质巯基(GSH ) 地位很好被保存。细胞色素 P450 系统并且每类脂化合物的氧化被 RMP 暴露导致。部分保护在肝对导致 RMP 的变化与 NAC 被观察，它在草皮和过氧化氢酶酶层次每氧化和减小从类脂化合物的增加的预防被证实。结论：NAC 保护小老鼠免于导致 RMP 的氧化肝的损害。
Cite
Citations (0)
When administered early after an overdose of acetaminophen, intravenous acetylcysteine prevents hepatic necrosis by replenishing reduced stores of glutathione. How acetylcysteine improves the survival of patients with established liver damage induced by acetaminophen, however, is unknown. This study was undertaken to determine whether the beneficial effect of acetylcysteine under such circumstances could be due to enhancement of oxygen delivery and consumption.
Fulminant hepatic failure
Acetaminophen
acetaminophen overdose
Fulminant
Oxygen transport
Cite
Citations (597)
Cellular infiltration
Infiltration (HVAC)
Cite
Citations (21)
Acetaminophen
Cite
Citations (34)
Acetaminophen
acetaminophen overdose
Cite
Citations (0)