Comparing the pelvis of Tibetan and Chinese Han women in rural areas of China: two population-based studies using coarsened exact matching
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This study aims to investigate the difference of pelvic size and shape between Tibetan and Chinese Han women. Data on pelvic dimension measures including interspinous diameter (IS), intercrestal diameter (IC), external conjugate (EC) and transverse outlet (TO) were acquired from two population-based studies amongst Tibetan women in Lhasa, and Chinese Han women in Shaanxi province in China. After coarsened exact matching, there was no statistical difference between any characteristics amongst Tibetan and Chinese Han women (p>.05). The generalised estimating equation models showed Tibetan women had significantly lower IS and IC means than Chinese Han women (IS: 24.39 cm vs. 24.77 cm, p<.001; IC: 26.35 cm vs. 26.93 cm, p<.001) but statistically higher in TO mean (9.12 cm vs. 9.03 cm, p<.001). This study showed Tibetan women have smaller pelvis compared to Chinese Han women. This should offer a useful literature on the comparison of pelvis between Tibetan and Chinese Han women although the difference is small.Impact StatementWhat is already known on this subject? Previous studies in China indicated different populations have different dimensions of pelvis, with the pelvis of Uighur women being bigger than Chinese Han women, and that of Zhuang and Tu women being smaller than Chinese Han women. Little research reports the specific size of Tibetan women's pelvis. Living at high altitude, the Tibetan population have differentiated demographics and show local adaptions, such as unelevated haemoglobin, and significant catch-up growth for infants compared with Chinese Han infants. Therefore, there is a strong rationale for better understanding pelvic characteristics amongst this population.What the results of this study add? This study showed Tibetan women have smaller pelvises compared to Chinese Han women. Tibetan women have a smaller interspinous diameter and intercrestal diameter than Chinese Han women, which leads to relatively narrow hip.What the implications are of these findings for clinical practice and/or further research? This study provides useful comparative information on pelvic features between Tibetan and Chinese Han women although the findings of differences were small. In addition, during the formulation of women's health policy, the results of this study can provide data to support the selection of appropriate indicators of obstetrics and gynaecology for different populations of pregnant women during antenatal care and delivery.Keywords:
Chinese population
Han Chinese
Demographics
Chinese people
Objective To investigate the vascular endothelial growth factor(VEGF) gene variations in the promoter region in Chinese Han population.Methods The polymorphisms of 300 Chinese Han healthy individuals from Northern China were analyzed using the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or direct sequencing.The commercial statistics package SPPS11.5 was used to compare the distribution of the allele and the genotype,and to analyze their correlations with the data on European reported.Results Significant differences were observed between European and Chinese Han healthy individuals with regards to the frequencies of the genotype and allele for-2578C/A and-1154G/A(P 0.01) Conclusion The frequency of-2578A/A,-1154G/G genotypes in Chinese Han population is significantly lower than that in European.
Han Chinese
Chinese population
European population
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This study aims to investigate the difference of pelvic size and shape between Tibetan and Chinese Han women. Data on pelvic dimension measures including interspinous diameter (IS), intercrestal diameter (IC), external conjugate (EC) and transverse outlet (TO) were acquired from two population-based studies amongst Tibetan women in Lhasa, and Chinese Han women in Shaanxi province in China. After coarsened exact matching, there was no statistical difference between any characteristics amongst Tibetan and Chinese Han women (p>.05). The generalised estimating equation models showed Tibetan women had significantly lower IS and IC means than Chinese Han women (IS: 24.39 cm vs. 24.77 cm, p<.001; IC: 26.35 cm vs. 26.93 cm, p<.001) but statistically higher in TO mean (9.12 cm vs. 9.03 cm, p<.001). This study showed Tibetan women have smaller pelvis compared to Chinese Han women. This should offer a useful literature on the comparison of pelvis between Tibetan and Chinese Han women although the difference is small.Impact StatementWhat is already known on this subject? Previous studies in China indicated different populations have different dimensions of pelvis, with the pelvis of Uighur women being bigger than Chinese Han women, and that of Zhuang and Tu women being smaller than Chinese Han women. Little research reports the specific size of Tibetan women's pelvis. Living at high altitude, the Tibetan population have differentiated demographics and show local adaptions, such as unelevated haemoglobin, and significant catch-up growth for infants compared with Chinese Han infants. Therefore, there is a strong rationale for better understanding pelvic characteristics amongst this population.What the results of this study add? This study showed Tibetan women have smaller pelvises compared to Chinese Han women. Tibetan women have a smaller interspinous diameter and intercrestal diameter than Chinese Han women, which leads to relatively narrow hip.What the implications are of these findings for clinical practice and/or further research? This study provides useful comparative information on pelvic features between Tibetan and Chinese Han women although the findings of differences were small. In addition, during the formulation of women's health policy, the results of this study can provide data to support the selection of appropriate indicators of obstetrics and gynaecology for different populations of pregnant women during antenatal care and delivery.
Chinese population
Han Chinese
Demographics
Chinese people
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The population of Han Chinese is ∼1.226 billion people. Genetic heterogeneity between northern Han Chinese (N-Han) and southern Han Chinese (S-Han) has been demonstrated by recent genome-wide studies. As an initial step toward health disparities and personalized medicine in Chinese population, this study developed a set of ancestry informative markers (AIM) for Han Chinese population.
Han Chinese
Genetic genealogy
Chinese population
Chinese people
Ancestry-informative marker
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Chinese people
Chinese population
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Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population
Background: Genetic susceptibilities play a large role in the pathogenesis of lung cancer (LC).The polycomb repressive complex 2 (PRC2) is a conserved chromatin-associated complex that represses gene expression and is crucial for proper organismal development and gene expression patterns.Despite PRC2 dysregulation has been observed in various human cancers, the relationship between PRC2 genes variants and lung cancer risk remains largely unexplored.Methods: To investigate the association between single nucleotide polymorphisms (SNPs) in PRC2 genes and the risk of developing LC, we genotyped blood genomic DNA from 270 LC patients and 452 healthy individuals of Chinese Han ethnicity using the TaqMan™ genotyping technique.Results: We found that rs17171119T>G(adjusted odds ratio (OR) = 0.662, 95% CI: 0.467-0.938,P < 0.05), rs10898459 T>C(adjusted OR = 0.615, 95% CI: 0.4-0.947,P < 0.05), and rs1136258 C>T(adjusted OR = 0.273, 95% CI: 0.186-0.401,P < 0.001) were significantly associated with a reduced risk of LC.Stratified analysis revealed a protective effect of rs17171119 in both male and female patients, specifically those with lung adenocarcinoma (LUAD).Additionally, rs1391221 showed a protective effect in both the LUAD and lung squamous cell carcinoma (LUSC) groups, while rs1136258 exhibited a protective effect in both females and males, as well as in both LUAD and LUSC groups.Furthermore, analysis of The Cancer Genome Atlas (TCGA) dataset revealed expression levels of EED and RBBP4 in both LUAD and LUSC. Conclusion:This study provides evidence that allelic variants in EZH2, EED, and RBBP4 may act as protective factors against LC development and could serve as genetic markers associated with susceptibility to LC.
Han Chinese
Chinese population
Association (psychology)
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To investigate the distribution of Colton, Diego, Kell and Yt rare blood groups in Chinese Nanjing Han population, so as to improve the transfusion capability of patients with rare blood group and to further enrich the rare-blood-donor bank.A total of 2 015 blood samples from the blood donors were selected randomly to screen the presence of K⁺ and Kp(c+) (Kell), Yt(b+) (Yt), Co(b+) (Colton), Di(a+b+) and Di(a+b-) (Digeo) antigen allele by using PCR and multiplex PCR.Out of 2005 samples, 1 case with K⁺ gene, 8 cases with Yt(b+) gene and 100 cases with Di(a+b+) gene, 2 cases with Di(a+b-) were identified, while no Kp(c+) and Co(b+) were detected.The frequencies of K⁺, Yt(b+) and Di(a+), Di(b+) are 0.0003, 0.0013 and 0.0258, 0.9742, respectively. They are very rare blood groups in Chinese Nanjing Han population.
Han Chinese
Chinese population
Group B
Group A
Blood bank
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POPULATION: Chinese Han and Thai.
Chinese population
Han Chinese
Chinese people
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Objective To investigate thiopurine methyltransferase(TPMT) activity distribution in Chinese Han and Yao population. Methods TPMT activity of erythrocyte (RBC) in healthy subjects was measured by RP-HPLC method. Results The mean values of TPMT activity were (11.96±3.27)nmol·h~ -1·mL~ -1 packed RBC in 273 healthy Chinese Han adults, (13.02±2.78)nmol·h~ -1·mL~ -1 packed RBC in 88 healthy Chinese Han children, and(13.27±3.92)nmol·h~ -1·mL~ -1 packed RBC in 148 healthy Chinese Yao children, respectively. No subject had hardly detectable erythrocye TPMT activity. The frequency distribution histogram in Chinese Han and Chinese Yao children appeared to be normal. There was no statistically significant in TPMT acitvity between Chinese Yao children and Han children, and there was no gender differences in TPMT activity. There was no significant age-related differences in TPMT activity in the Chinese Han adults and Chinese Han children. However, TPMT activity correlated positively with age in Chinese Yao children with a small value of γ (γ= 0.2596). Conclusion The frequency distribtion of TPMT activity was unimodal in Chinese Han and Yao population.
Thiopurine methyltransferase
Han Chinese
Chinese population
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Objective:To find out the gene polymorphism of angiotensin I-converting enzyme(ACE) in healthy population of Chinese She and Chinese Han people in Zhejiang area.Methods:The PCR was used to detect the insert or defect(I/D) gene polymorphism of ACE in 201 Chinese She and 204 Chinese Han people in Zhejiang area.The results were differential counted and analyzed with statistical software.Results:The frequency of II,ID and DD type is 25.9%,32.8% and 41.3% respectively in Chinese She people,and the frequency is 45.1%,41.2% and 13.7% in Chinese Han people respectively.Conclusion:The distribution of gene polymorphism of ACE is unrelated to sex,and there are differences in the distribution of gene polymorphism of ACE between Chinese She and Han people in Zhejiang area.
Han Chinese
Chinese population
Chinese people
Gene polymorphism
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