VIRUS-ASSOCIATED HEPATOCELLULAR LIVER CANCER
7
Citation
15
Reference
10
Related Paper
Citation Trend
Abstract:
The review presents epidemiological data on the prevalence of hepatocellular liver cancer (HCC) in different countries of the world including the Republic of Belarus, that belongs to the countries with a low prevalence of HCC. The review also contains information about variants of liver cancer associated with various hepatotropic viruses (HBV, HCV, HDV), the pathological process in which manifests itself as a mono or mixed viral infection. The mechanisms of transformation of an infectious process into an oncological one are considered. The importance of liver cirrhosis fibrosis in the development of cancer as a competing disease, the peculiarities of the morphological picture in the liver and the effect of therapy on the course of cirrhosis and hepatocellular liver cancer are emphasized.Keywords:
Liver Cancer
Hepatocellular cancer
Viral Hepatitis
Liver disease
Objective To investigate the clinical efficacy of liver cancer resection combined with splenectomy in treatment of the hepatocellular cancer patients with hypersplenism.Method The data of liver function,changes of platelet count and white blood cell count in 12 hepatocellular cancer patients with hypersplenism were analyzed retrospectively.Results Three days after operation,the white blood cell count increased from(3.2 ± 1.7) × 109 /L to(13.5 ± 5.3) × 109 /L,the platelet count increased from(52.6 ± 23.7) × 109 /L to(245.3 ± 94.6) × 109 /L(P 0.01).The major parameters of the liver function recovered to their preoperational values within 1 week.Conclusion Liver cancer resection combined with splenectomy was effective for treatment of the hepatocellular cancer patients with hypersplenism.
Liver Cancer
Hepatocellular cancer
White blood cell
Liver function
Cite
Citations (0)
Viral Hepatitis
Liver disease
Cite
Citations (19)
Viral Hepatitis
Liver disease
Cite
Citations (0)
Hepatocellular cancer
Liver Cancer
Cancer Incidence
Primary cancer
Cite
Citations (4)
The review presents epidemiological data on the prevalence of hepatocellular liver cancer (HCC) in different countries of the world including the Republic of Belarus, that belongs to the countries with a low prevalence of HCC. The review also contains information about variants of liver cancer associated with various hepatotropic viruses (HBV, HCV, HDV), the pathological process in which manifests itself as a mono or mixed viral infection. The mechanisms of transformation of an infectious process into an oncological one are considered. The importance of liver cirrhosis fibrosis in the development of cancer as a competing disease, the peculiarities of the morphological picture in the liver and the effect of therapy on the course of cirrhosis and hepatocellular liver cancer are emphasized.
Liver Cancer
Hepatocellular cancer
Viral Hepatitis
Liver disease
Cite
Citations (7)
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare (< 1%) primary liver cancer which contains elements of hepatocellular cancer (HCC) and bile duct cancer (CC). On account of the difficulties in reaching preoperative diagnosis, it is frequently diagnosed only after resection is performed. A surgical resection of the liver is the treatment of choice, whilst a liver transplant is a rarely implemented option. The prognosis of cHCC-CC tumours is better than in CC but worse than in HCC. This paper presents the case report of a 62-year-old man undergoing a left hemihepatectomy for a cHCC-CC liver tumour.
Hepatocellular cancer
Liver Cancer
Bile duct cancer
Cite
Citations (0)
Patient records from the Guam Cancer Registry were compared with patients listed in a health department viral hepatitis case registry and the numbers of liver cancer and viral hepatitis cases were compared by ethnicity. Hepatitis C was the form of viral hepatitis most common among liver cancer cases on Guam (63.3% of viral hepatitis-associated liver cancer cases). Since viral hepatitis is an important cause of liver cancer, studies such as the present one may provide the information necessary to establish programs (screening of populations at risk and infant vaccination in the case of hepatitis B, for example) that may lessen the impact of liver cancer in the future.
Viral Hepatitis
Liver Cancer
Hepatitis C
Hepatitis B
Cite
Citations (10)
Objective To investigate the proportion of pediatric non-viral liver disease to pediatric liver disease,liver dis-ease spectrum and its proportion so as to provide evidence for the prevention and treatment of pediatric non-viral liver disease.Methods Clinical data of 703 pediatric patients with non-viral liver disease,who were admitted to our hospital from Jan.2001 to Dec.2010 and received liver biopsy,were analyzed retrospectively,and compared with that of the pediatric patients with non-viral liver disease admitted from Jun.1983 to Dec.2000.Results The proportion of pediatric non-viral liver disease to pediatric liver dis-ease was 17.53% from Jan.2001 to Dec.2010,with an increasing tendency,especially during the past two years (an increase of over 20%).The difference was significant between the proportion from Jan.2001 to Dec.2010 and that from Jun.1983 and Dec.2000 (χ2=38.129,P=0.000).The spectrum of pediatric non-viral liver disease covered 66 kinds of liver diseases in the enrolled individu-als from Jan.2001 to Dec.2010.Among them,hepatic metabolism-related disease accounted for the largest proportion (46.23%),among which hepatolenticular degeneration accounted for 48.92% of the single disease.Biliary-related disease accounted for 11.66%,drug-induced hepatitis 10.53% and non-alcoholic fatty liver disease 7.45%.It could not be ignored that the incidence of non-viral liver disease combined with viral hepatitis was 11.2%.The final diagnosis of 4.8% intractable cases of pediatric non-viral liver dis-ease was confirmed by some special methods such as genetic technology,etc.Conclusions The number of the patients with pedi-atric non-viral liver disease has surprisingly increased in China over the past 10 years.The liver disease spectrum has expanded quickly and the proportion has changed significantly compared with the past.It can not be ignored that the number of pediatric pa-tients with non-viral liver disease combined with viral hepatitis is not small.Furthermore,the development of diagnostic technique contributes to the confirmed diagnosis of intractable cases of pediatric non-viral liver disease.
Viral Hepatitis
Liver disease
Hepatitis C
Cite
Citations (0)
Background: The burden of liver diseases in India has witnessed a significant rise, spurred by factors such as viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and a spectrum of metabolic and genetic disorders. Liver function tests (LFTs) serve as invaluable tools in the hands of clinicians, offering insights into the dynamic interplay between hepatic health and various disease processes. This study aims to provide a detailed exploration of the alterations in LFTs associated with various liver diseases prevalent in India. Aim and Objectives: (i) To Identify the various types of Liver diseases; (ii) To evaluate the various liver function tests in various liver diseases. Materials and Methods: The study involved the collection of samples from 100 liver disease patients who seek medical care at C. U. Shah Medical College and Hospital. Informed consent was obtained from all participants and the study protocol was approved by the institutional ethics committee. Results: Our study shows that the prevalence of cirrhosis of liver was 25% among study participants. Majority of liver disease were prevalent in male whereas, mostly affected age group was 51–60 years. Bilirubin was altered in cirrhosis of liver (88%), obstructive jaundice (100%), alcoholic liver disease (80%), viral hepatitis (75%), and in other liver disease (85%). Conclusion: Altered LFT is a useful tool to reach the Etiology of Liver disease. Alterations in liver enzymes as well as HbsAg reactivity are specific tests for cirrhosis of liver and viral hepatitis.
Liver disease
Viral Hepatitis
Liver function
Hepatitis C
Hepatitis B
Alcoholic Hepatitis
Cite
Citations (1)
Objective:To observe the level of plasma P-selectin(P-sel)in patients with liver cancer,chronic viral hepatitis B and liver cirrhosis and to study the clinical significance of it.Methods: The concetration of P-sel in plasma of 53 patients with liver cancer at different clinical stage, 22 patients with viral hepatitis B, 14 patients with liver cirrhosis and 30 normal volunteers were determined with ELISA method.Results:The results shown that the level of P-sel was elevated in all subgroups of patients with liver cancer, viral hepatitis B and liver cirrhosis compared to control. The P-sel concentration of liver cancer were highter than that of viral hepatitis B and liver cirrhosis, liver cirrhossis highter than that of viral hepatitis B. The P-sel of liver cancer in stage ⅢandⅣwere higher in comparison with stage Ⅰand stage Ⅱ. The P-sel concentration was positively corrlated with ALT,AST,GGT,TB and DB levels in liver cancer. Conclusion: It is suggested that the elevation of P-sel reult from the activation or destroy of platelet and endothelia cell. Liver dysfunction seems to play an importent part in the increase of plasma P-sel in liver cancer. Measurement of plasma P-sel might therefore provide a tool for monitoring the clinical course of liver cancer.
Liver Cancer
Viral Hepatitis
Hepatitis B
Clinical Significance
Cite
Citations (0)