EBV+ lymphoproliferative diseases: opportunities for leveraging EBV as a therapeutic target
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Lymphoproliferative Disorders
Lymphoproliferative disease
Lymphoproliferative Disorders
Immune Dysregulation
Epstein–Barr virus infection
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リンパ増殖性疾患の診断には,理学的所見としてリンパ節腫脹.検査所見として末梢血異常,すなわちリンパ球増加などが認められることによって,その存在が予測される.確定診断には,リンパ節生検による組織検査,および免疫組織学的・免疫細胞学的検索が必須である.末梢血異常を認めた場合は,リンパ球の形態学的検索と細胞表面形質の検索が重要である.
Lymphoproliferative disease
Lymphoproliferative Disorders
Autoimmune lymphoproliferative syndrome
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Epstein–Barr virus infection
Gammaherpesvirinae
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Lymphoproliferative Disorders
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T-cell posttransplant lymphoproliferative disorders are rare, with peripheral T-cell lymphoma not otherwise specified being the most common type. Although cases of the signet ring cell variant of primary cutaneous CD30+ lymphoproliferative disorder have been reported, such cases have not been described in the posttransplant setting. We describe a case with emphasis on the special contextual differential diagnostic considerations.
Lymphoproliferative Disorders
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Abstract By means of a PCR assay, EBV was demonstrated directly in peripheral blood of previously infected individuals. The virus was detected in approximately 80% of specimens from EBV‐seropositive individuals, but not in cord‐blood lymphocytes by this method. When virus present in peripheral blood was compared to that observed directly in NPC biopsies or throat washings, it was distinct from that seen in biopsies in 4/15 cases (17%) and from that seen in throat washes in 1/22 cases (5%). The throat‐wash virus differed from the biopsy virus in 3/20 cases (15%). The prototype F virus was found in 7/10 LCLs (70%) established from NPC patients' peripheral blood, but was only detected in 2/9 specimens (22%) directly analyzed by the PCR assay. This finding suggests selective isolation of prototype F EBV in spontaneous LCLs established from NPC patients. © 1992 Wiley‐Liss, Inc.
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Solid-organ and hematopoietic stem-cell transplants are widely used for various life-threatening medical disorders. Prophylaxis against transplant rejection and graft-versus-host disease is often immunosuppressive and can increase the risk of lymphoproliferative disease.
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Lymphoproliferative disease
Solid organ
Post-transplant lymphoproliferative disorder
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Fifteen allograft transplant recipients acquired lymphoproliferative disorders after immunosuppressive therapy with cyclosporine and steroids. Many of these lymphoproliferative disorders regressed or disappeared completely after reduction of cyclosporine dose. This disease has several aspects that distinguish it from usual posttransplantation lymphomas that occur with regimens that do not contain cyclosporine. The time course from transplantation to onset of lymphoma is relatively short, with an average of approximately 8 months. Organs show a wide spectrum of abnormalities typical of other immunosuppression-associated lymphomas, but there is unique sparing of the central nervous system. The tumor is also unique in that it responds to a decrease in the cyclosporine dose.
Immunosuppression
Lymphoproliferative Disorders
Lymphoproliferative disease
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Primary cultures of epithelial cells were grown from the tonsils and adenoids of patients with diseases not related to Epstein-Barr virus. The cells could not be infected by Epstein-Barr virus. Fluorescein-labeled Epstein-Barr virus and a cytofluorograph were then used to show that the epithelial cells do not have detectable receptors for the virus. However, implantation with Epstein-Barr virus receptors gave the cells the ability to bind the labeled virus. One to 5 percent of receptor-implanted cells exposed to the transforming B95-8 substrain of the virus expressed Epstein-Barr nuclear antigen. The early and viral capsid Epstein-Barr virus-determined antigens were not detected in the virus-infected cultures. The results show that normal human epithelial cells from the nasopharynx become susceptible to infection by Epstein-Barr virus when the membrane barrier resulting from the lack of viral receptors is overcome by receptor implantation.
Gammaherpesvirinae
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Epstein–Barr virus infection
Gammaherpesvirinae
Oncovirus
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