What are the effects of gonadotropin-releasing hormone agonists administered before in vitro fertilization/intracytoplasmic sperm injection for women with endometriosis?
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STUDY QUESTIONDoes ovarian hyperstimulation, the in vitro procedures required for in vitro fertilization (IVF)/ intracytoplasmic sperm injection or the combination of both, affect the neurological outcome of 4-year-old singletons?
Controlled ovarian hyperstimulation
Ovarian hyperstimulation syndrome
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Spontaneous conception
Assisted Reproductive Technology
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The objective of this meta-analysis is to assess the impact of LH supplementation in women undergoing in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) with gonadotropin releasing hormone (GnRH) antagonist protocol. No significant difference in outcomes between LH supplementation and r-FSH alone in women undergoing IVF/ICSI with GnRH antagonist protocol is currently present, and further studies are necessary for more solid conclusions on pregnancy likelihood to be drawn.
Gonadotropin-releasing hormone antagonist
Hormone antagonist
Gonadotropin
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Objective To evaluate the clinical use of intracytoplasmic sperm injection when fertilization cycles in vitro failed. Methods Reinsemination by using of intracytoplasmic sperm injection was carried out 24 h after oocytes retrieval in the failed fertilization cycles in vitro. Results A total of 127 one-day-old Mu oocytes from 14 failed fertilization cycles in vitro were subjected to intracyto- plasmic sperm injection. Among them, 105 were survived(82. 7%), 15 polyploidic (11. 8%), and 71 (55. 9%) fertilized normally, of which, 61(85.9%) cleaved. Thirty-two embryos were trans- ferred to 13 patients. One patient (7.7%) conceived after ET. Conclusions Intracytoplasmic sperm injection can be used when fertilization cycles in vitro failed for either diagnostic or thera- peutic purpose, but the pregnancy rates seems not high.
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Gonadotropin
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This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the relative effectiveness of post‐embryo transfer techniques on women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
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Aims: In this self-matched observational study, the factors associated with the presence of tripronuclear (3PN) embryos, in conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles using gonadotropin-releasing hormone agonist long protocols, were investigated. Material & Methods: Clinical parameters were analyzed in 202 consecutive IVF-IVF or ICSI-ICSI matched cycles. The differences between the former and latter cycles were evaluated and compared according to the presence of 3PN embryos: group A [3PN (−) followed by 3PN (−)]; group B [3PN (−) followed by 3PN (+)]; group C [3PN (+) followed by 3PN (−)]; group D [3PN (+) followed by 3PN (+)]. Results: For the IVF-IVF cycles, the E2 on human chorionic gonadotropin injection day and the number of retrieved oocytes were increased in the 3PN (+) cycles compared to the 3PN (−) cycles of Groups B (2165.2 ± 1423.3 pg/mL vs 1468.2 ± 796.2 pg/mL, P = 0.016; 10.4 ± 9.1 vs 7.2 ± 5.7, P = 0.010) and C (2382.7 ± 1214.5 pg/mL vs 1553.0 ± 1119.6 pg/mL, P = 0.004; 13.1 ± 9.1 vs 9.1 ± 7.0, P < 0.001), while these outcome variables did not differ when the former and latter cycles in Groups A and D were compared. These trends were observed in the ICSI-ICSI cycles. Conclusions: An increased responsiveness, based on the higher E2 and greater number of retrieved oocytes, may be associated with the presence of 3PN in both conventional IVF and ICSI cycles.
Human chorionic gonadotropin
Gonadotropin
Gonadotropin-releasing hormone agonist
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