Influence of azithromycin and allograft rejection on the post–lung transplant microbiota
C. SpenceBart M. VanaudenaerdeG.G. EinarssonJohn E. McDonoughAndrew LeeE. JohnstonGeert M. VerledenJ.S. ElbornLieven DupontAnke Van HerckD.F. GilpinRobin VosMichael M. TunneyStijn E. Verleden
28
Citation
30
Reference
10
Related Paper
Citation Trend
Objectives:To evaluate the efficacy and safety of azithromycin injection compared with clarithromycin in the treatment of acute bacterial infections. Methods: A total of 160 patients were included in this study, 60 cases of respiratory infections treated with azithromycin were compared with 60 cases treated with clarithromycin, 40 cases of other tissue infections were treated with azithromycin. Drugs were administered intravenously once daily (for azithromycin) or twice daily (for clarithromycin) for 5~7 days, at a daily dose of 0.5 g of azithromycin or 1.0 g of clarithromycin. Results: The overall clinical efficacious rates of azithromycin was 92.0%. There was no significant difference( P 0.05) between azithromycin and clarithromycin in the clinical efficacy and bacterial clearance rates. The incidence of adverse drug reactions for azithromycin (15%)was lower than that for clarithromycin(45.0%, P 0.05 ). Conclusions: Azithromycin injection is an effective and safe antibiotics for the treatment of bacterial infection.
Cite
Citations (0)
Cite
Citations (54)
Regimen
Oral dose
Cite
Citations (28)
Cite
Citations (1)
Neutrophilia
Cite
Citations (2)
This paper mainly studies the therapeutic effect of azithromycin and hydroxychloroquine on COVID-19. Severe acute respiratory syndrome is one of the key clinical manifestations of COVID-19, and azithromycin is considered to be a feasible treatment. The purpose of this study is to investigate how to use azithromycin to treat COVID-19 better. This article describes the therapeutic effect of azithromycin alone on COVID-19, and the effect of azithromycin and hydroxychloroquine when used in combination with COVID-19. Several studies have shown that although azithromycin has antiviral activity, azithromycin alone has no significant effect on the treatment of COVID-19. In contrast, multiple data show that the combination of azithromycin and hydroxychloroquine has some efficacy in the treatment of COVID-19, and the efficacy is related to the number of days the patient has been ill. The discovery impacts the treatment by providing a different perspective on the world’s treatment of COVID-19.
Hydroxychloroquine
Cite
Citations (0)
Obstructive lung disease
Cite
Citations (8)
OBJECTIVE: To study the general regularity and clinical characteristics of adverse drug reaction (ADR) caused by azithromycin, and to provide reference for rational use of drugs in the clinic. METHODS: A case reported a child of 10 years old suffered from cholecystolithiasis due to azithromycin therapy. Retrieved from Wanfang database, publicly issued literatures about azithromycin-induced ADR reported in domestic pharmaceutical journals from 2001 to 2010 were collected and analyzed. RESULTS: Azithromycin-inducing ADR mainly was anaphylactic shock, followed by the damage of dermal system and digestive system. Azithromycin-inducing ADR often occurred in children under 10 years of age. CONCLUSION: We should pay more attention to azithromycin-inducing ADR, select the appropriate route of administration and ensure the safety of drug use.
Anaphylactic shock
Adverse drug reaction
Drug reaction
Cite
Citations (0)
Lung infection
Cite
Citations (10)
Purpese: Lung transplantation is now accepted as an effective therapy for end-stage pulmonary vascular and parenchymal diseases. Rejection is a major impediment to long-term survival of lung transplant recipients. Lung allograft rejection has been studied in various animal models. To study the immunological mechanism of its rejection the studies on lung allograft rejection must be performed in inbred animals such as mice or rats, However, it is very delicate and difficult to transplant the lung in small inbred animals, especially in mice. The technical difficulty hampered the investigations of lung allograft rejection. Methods: This study introduced the new lung transplantation technique in mice for immunological study, subcutaneous lung tissue transplantation, in which the piece of lung tissue with 1-1.5 mm thickness was introduced subcutaneously through incision site on flank and transplanted to subcutaneous site of shoulder of mouse. Histological changes were followed up in transplanted lung tissues for 18 to 21 days. Lung tissues from CBA mice or Balb/c mice were subcutaneously transplanted to Balb/c mice in experimental or control group respectively. Results: Histological changes in the grafts of experimental groups could be divided into 4 phases, inflammatory, immunological, necrotic and fibrotic phase, Immunological or necrotic phase in this study correlated with grade 1-3 or grade 3-4 of acute lung rejection classified by the Lung Rejection Study Group. Conclusion: It is concluded that the subcutaneous lung tissue transplantation can be a technique for immunological study on acute lung allograft rejection in mice.
Parenchyma
Cite
Citations (0)