A Simple One‐Pot Synthesis of N‐Alkyl‐2,5‐diaryl‐1,3‐dioxol‐4‐amines
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Abstract An efficient procedure for the synthesis of N ‐alkyl‐2,5‐diaryl‐1,3‐dioxol‐4‐amines 3 via a one‐pot reaction of aromatic aldehydes 2 and alkyl isocyanides 1 at room temperature in good yields is described ( Scheme 1, Table ).Keywords:
One-pot synthesis
In this article, we present new results on simple points, minimal non-simple sets (MNS) and P-simple points. In particular, we propose new characterizations which hold in dimensions 2, 3 and 4, and which lead to efficient algorithms for detecting such points or sets. This work is settled in the framework of cubical complexes, and some of the main results are based on the properties of critical kernels.
SIMPLE algorithm
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Gas chromatographic studies have shown that the weak interaction between an alkane sample and the phenyl group in a stationary liquid varies in strength with the geometrical shape of the alkyl group and is more attractive for a cyclic alkyl group than for the corresponding straight-chain alkyl group.
Alkane
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One-pot synthesis
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Carbon chain
Side chain
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Sonogashira coupling
Tandem
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Cascade reaction
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Abstract I 2 /Cs 2 CO 3 mediated metal free methodology to synthesize symmetrical and unsymmetrical 3,5‐disubstituted‐1H‐1,2,4‐triazole derivatives from amidines and imidates involving one‐pot C—N and N—N bond formation is reported.
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Beta-Hydride elimination
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[reaction: see text] In the reaction of p-chlorophenyl alkyl sulfides with IF(5), polyfluorination reaction took place on the alkyl chain with the migration of the arylthio group. Consequently, p-chlorophenyl polyfluoroalkyl sulfides, having 3-7 fluorine atoms depending on alkyl chain length, could be obtained selectively.
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Fluorine
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Abstract Water as a cosolvent has significant improving effect on the reductivity of SmI2 in the reduction of sodium alkyl thiosulfates and alkyl thiocyanates. A new method for synthesis of alkyl thiols by SmI2/THF/H2O system has been developed.
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In modern synthetic chemistry, the formation of multiple C-C bonds in a limited number of steps to access both diversity and complexity has become an important challenge. In recent years, significant research has been devoted to the synthesis of 1,2,3-triazole containing compounds in a multimetal-catalyzed domino sequence due to the remarkable biological activity and pharmaceutical potency of these compounds. Considering the increasing significance of 1,2,3-triazoles in synthetic chemistry, mixing all of the starting components in a one-pot, one-step process to create the final triazole product will be highly efficient with respect to time, cost and simplicity of performance. A number of published papers illustrated the diverse applications of 1,2,3-triazoles (e.g., palladium-mediated couplings and direct C-H bond functionalization). Similarly, this work demonstrates the development of a highly efficient and practical approach to the synthesis of these versatile triazole-containing motifs via a one-pot, one-step cascade process that involves Sonogashira, Heck and carbopalladation/annulation reactions.%%%%M.Sc.%%%%2017-11-23 00:00:00
Sonogashira coupling
Annulation
One-pot synthesis
Domino
Triazole
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