0156: Hyperglycemia on admission predicts severity of coronary artery lesions in patients admitted for acute myocardial infarction
0
Citation
0
Reference
10
Related Paper
Abstract:
High blood glucose (HBG) on admission is a major common metabolic disorder in patients with acute myocardial infarction (MI). However, only few data have examined its predictive performance over established risk score. The aim of our study was to determine if hyperglycemia on admission correlates to severity of coronary artery lesions evaluated by the Synthax score. We evaluated 93 patients admitted for MI. The population was divided into: hyperglycemia (glycemia on admission >1.10g/l) and non-hyper-glycemia (<1.10g/l) regardless of previous diabetic status. 63.4% of our patients presented with hyperglycemia on admission. Patients aged over 65 years old represented 89% of the population studied. There were significant differences in baseline clinical status established by calculating CHADSVASC score (2,60±1,54 vs 1,5±1,05; p=0.01). Biological status differed significantly between the two groups especially troponine Ic, LDL cholesterol and triglyceride which were higher in HBG patients (32,20±63,93 vs 17,64±31,16 p=0.014; 0,94±0,33 vs 0,87±0,27 p=0.015; 1,45±0,67 vs 1,16±,42 p=0.04 respectively). Synthax score was higher in the hyperglycemia group 11,21±8,377 vs 7,50±8,782 p=0.03. A multivariate linear regression analysis showed that hyperglycemia on admission was an independent predictor of severity of coronary artery lesions. In patients with MI, hyperglycemia on admission predicts severity of coronary artery lesions so we should be more careful with this population.Keywords:
Population study
The purpose of this study is to further confirm the results documented in previous studies and to test the hypothesis of the presence of any correlation and if found, the regression nature of such correlation between triglyceride and glucose levels in one hand and cholesterol and glucose levels in the other hand.Samples were collected between March and August 2009 from 438 of both males and females from two patient groups; a) non-diabetic patients, b) non-insulin dependent type II diabetic patients. The patients' serum glucose; cholesterol and triglyceride were simultaneously determined. A comparison study was conducted on the effect of the elevated level of each of the parameters (Cholesterol and Triglyceride) on glucose elevation.The results showed that there was a significant difference in the number of cases with high glucose values >110 mg/dl among the three different study groups. There was a significant difference in the number of cases with glucose values >110 mg/dl between the two different study groups; 1) triglyceride <151 mg/dl and cholesterol >201 mg/dl, 2) triglyceride >151 mg/dl and cholesterol>201 mg/dl.The elevation in triglyceride but not cholesterol has the same effect of both triglyceride and cholesterol elevation together on the association with increasing levels of high glucose in blood.
Serum glucose
Cite
Citations (12)
The effect of feeding diets containing 75% glucose or fructose on liver triglyceride formation in the rat was studied by both in vivo and in vitro techniques. The results were compared with those from control rats fed laboratory chow.
Steatosis
Cite
Citations (74)
Objective To study the effects of the Yinlingtong capsules on intracellular triglyceride,fatty acid oxidation levels and CPT-1/ACC-β in HHL-5 cells.Methods After treated HHL-5 cells with different doses Yinlingtong capsules,intracellular triglyceride content and the fatty acid oxidation level were detected by the kits.The CPT-1β and ACC-β mRNA levels were detected by Q-PCR.Results Yinlingtong capsules could reduce triglyceride content (compared with the control group,triglyceride content of0.5,1 and 2 mg/ml dose group were reduced by 9.5％,14.3％ and 19.4％,respectively),enhance the level of fatty acid oxidation by a dose-response relationship(compared with the control group,the level of fatty acid oxidation of 0.5,1and 2 mg/ml dose group were increased 4.3％,6.9％ and 11.2％,respectively),but could not affect the CPT-1βand ACC-β mRNA levels.Conclusion Yinlingtong capsules reduced the accumulation of fat in HHL-5 hepatocytes,and the specific impact mechanism needs to be further explored.
Key words:
Triglyceride; Fatty acid oxidation level; CPT-1β; ACC-β
Cite
Citations (0)
【Objective】To investigate the correlation among serum triglyceride concentration,plasma factor Ⅶ clouting(FⅦc),tPA,PAI-I activity in 73 cases with coronary heart disease(CHD).【Methods】One hundred and fifty three cases were divided into four groups: 73 patients with CHD were divided into two groups based on serum triglyceride concentration.40 subjects with high triglyceride without CHD;another 40 subjects with normal triglyceride.The results in 73 patients with CHD and 40 subjects with high triglyceride were compared with those in 40 normal triglyceride.Serum triglyceride was measured by enzyme method.The plasma PA1-I,tPA activity were measured by spectrophotometry,the plasma FⅦc by one stage method.【Results】FⅦc and PAI-I activity in patients with CHD and in high serum triglyceride group were higher than those in normal triglyceride group.FⅦc and PAI-I activity in high triglyceride patients with CHD were significantly higher than those in high triglyceride cases without CHD.【Conclusion】Serum high triglyceride concentration is associatied with FⅦc,tPA and PAI-I.
Coagulative necrosis
Cite
Citations (0)
Trypsinization
Cite
Citations (21)
Objective:To investigate the effects of nucleocapsid protein(N protein) of severe acute respiratory syndrome coronavirus(SARS-CoV) on blood triglyceride and cholesterol.Methods:144 cases of SARS patients were analysed by testing the concentration of their blood triglyceride and cholesterol.Simultaneously twenty mice were randomly assigned to two groups which were continuously given physiological saline and SARS-CoV N protein for 9 days,then the changes of body weight,blood triglyceride and cholesterol were tested.Results:The concentration of blood triglyceride and cholesterol in the bodies of SARS patients increases in line with disease time(P0.05).The rising of blood triglyceride and cholesterol of patients around 40th day were observed,and the proportion of the patients who has high concentration of triglyceride or cholesterol around 40th day is higher than the proportion in other period.The body weight of mice in SARS-CoV N protein group was significantly higher than those in control group(P0.05).The concentration of triglyceride of mice in SARS-CoV N protein group was obviously higher than those in control group in the 39th and 51th day.The concentration of cholesterol in SARS-CoV N protein group was obviously higher than those in control group in the 21th and the 39th day(P0.05).Conclusion:Triglyc-eride and cholesterol levels of SARS patients changed obviously through disease time,and the levels obviously rose around 40 days.SARS-CoV N protein can increase the body weight and the levels of triglyceride and cholesterol of mice,and the increment was obvious around the 39th day which is consistent with SARS patients.It can be seen that SARS-CoV N protein is the important cause of increasing the concentration of triglyceride and cholesterol after SARS infection.
Cite
Citations (0)
42 patients with acute cerebral stroke (average age 70, 83ą9, 95 years) were examined for fluctuations in the level of serum triglyceride, total cholesterol, HDL-cholesterot and LDL-cholesterol within 24 hours after the acute event and on the eight day after the onset of symptoms. Patients did not receive specific hipolipemic drugs during the treatment. On the first day average values of serum triglyceride were 1, 97ą0, 94 ; of total cholesterol 5, 99 ą1, 91 ; of HDL-cholesterol 0, 86ą0, 35 and of LDL-cholesterol 3, 91ą1, 63 mmol/L. On the eight day average values of triglyceride were 2, 26ą2, 31 ; of total cholesterol 4, 59ą1, 49 ; of HDL-cholesterol 1, 2ą0, 54 and of LDL-cholesterol 2, 91ą1, 17 mmol/L. The results revealed a statistically significant (p<0, 05) decrease in total cholesterol and LDL-cholesterol and statistically significaiit increase in HDL-cholesterol, while there was no statistically significant difference between levels of triglyceride. We. conclude that in patients with acute cerebral stroke, triglyceride, total cholesterol and LDL cholesterol is increased, due to stress and increased secretion of catecholamines. On the eight day there is decrease in serum levels of triglyceride, total cholesterol and LDL-cholesterol, while HDL-cholesterol is increased. These changes are probably due to dietary changes after stroke, besides the fact that stress inducing catecholamines overproduction is no long acting.
Stroke
Cite
Citations (0)
식용자원의 하나인 고추씨 기름에 관하여 식품화학 및 유화학적인 기초자료를 얻기 위한 연구의 일환으로 고추씨 기름의 triglyceride조성을 분석하고, 중요한 고추 생산지 두 곳을 선정하여 산지별에 따른 그 차이를 비교 검토하였다. 즉 청송산 및 영양산 고추씨 기름의 triglyceride 조성을 밝히기 위하여 시료 유를 TLC에 의하여 triglyceride를 분석하고, HPLC로써 PN별로 분획한 후, 각 획분을 분취하여 GLC로써 acyl carbon number별로 분획하였다. 또한 PN별 획분을 GLC에 의하여 지방산 조성을 분석하였다. 그리고 이들 분석된 결과로 부터 triglyceride조성을 산정하였는데, 청송산 고추씨 기름은 14종류, 영양산은 18종류의 triglyceride로 구성되어 있었으며, 주요triglyceride는 청송산 고추씨기름이 (3×C_(18:0))가 39.6%, (C_(18:0)×C_(18:0))가 37.1%이었고, 영양산의 경우는 (3×C_(18:0))가 41.0%, (C_(18:0)×C_(18:0))가 36.3%이었다.
Cite
Citations (6)
The effects of age and sex on triglyceride metabolism were investigated in 3-mo-and 1-year-old rats. Although 3-mo-old female rats produce as much triglyceride as comparably aged male rats, their plasma triglyceride levels are lower. This suggests that 3-mo-old female rats remove triglycerides from plasma more efficiently than do similar aged male rats, and this is supported by the observation that the t½ of very low density lipoprotein triglyceride removal is somewhat faster in female rats of this age (p ≤ 0.1 ≥ 0.5). As rats grow to 1 year of age, the ability of both sexes to remove triglycerides from plasma deteriorates, resulting in a rise in plasma triglyceride levels. The decrease in efficiency of triglyceride removal from plasma in female rats is coupled with an increase in triglyceride production rate, leading to an even greater increase in triglyceride levels. These results indicate that both age and sex modify triglyceride metabolism in the rat.
Cite
Citations (22)
Objective:To investigate the correlation among serum triglyceride concentration, plasma factorⅦ clouting(FⅦc), tPA, PAI I activity in 73 cases with Coronary heart disease(CHD).Methods:153 Cases Were divided into four groups:73 patients with CHD were divided into two groups based on serum triglyceride concertration. 40 subjects have high triglyceride without CHD; another 40 subjects with normal triglyceride. The results in 73 patients with CHD and 40 Subjects With High triglyceride were compared with that in 40 normal triglyceride. Serum triglyceride was measured by enzyme method, The plasma PAI0 I, tPA activity by spectorphotometry, the plasma FⅦc by onestage method.Results:FⅦc and PAI I activity in patients with CHD and in serum high triglyceride group were higher than in those with normal triglyceride group. FⅦc and PAI I activity in high triglyceride patients with CHD were significantly higher than in those high triglyceride cases without CHD.Conclusion:Serum high triglyceride concentuition is associatied with FⅦc, tPA and PAI 1.
Cite
Citations (0)