Sperm retrieval by microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in nonobstructive azoospermic patients with Klinefelter syndrome
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Klinefelter syndrome is the most frequent chromosomal abnormality in patients with nonobstructive azoospermia. The development of advanced assisted reproductive techniques, such as testicular sperm extraction and intracytoplasmic sperm injection, has provided the possibility of biological fathering in nonobstructive azoospermic patients with Klinefelter syndrome. We aimed to evaluate our sperm retrieval rate by microdissection testicular sperm extraction and to analyse the intracytoplasmic sperm injection outcomes in these patients. Medical records of 110 nonobstructive azoospermic patients with Klinefelter syndrome were retrospectively reviewed. We found that the sperm retrieval rate by microdissection testicular sperm extraction is lower than published reports on other types of secretory azoospermia. The statistical analyses yielded that age, FSH and testosterone levels as predictive factors for successful sperm retrieval.Keywords:
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No AccessJournal of UrologyAdult Urology1 Aug 2014Re: Comparison of Sperm Retrieval and Intracytoplasmic Sperm Injection Outcome in Patients with and without Klinefelter Syndrome Craig NiederbergerMD Craig NiederbergerCraig Niederberger More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.05.041AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Comparison of Sperm Retrieval and Intracytoplasmic Sperm Injection Outcome in Patients with and without Klinefelter Syndrome." The Journal of Urology, 192(2), p. 503 © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 192Issue 2August 2014Page: 503Supplementary Materials Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.MetricsAuthor Information Craig Niederberger More articles by this author Expand All Advertisement PDF downloadLoading ...
Sperm Retrieval
Klinefelter syndrome
Testicular sperm extraction
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We evaluate microscopic (micro) testicular sperm extraction (TESE) timing relative to oocyte retrieval on intracytoplasmic sperm injection outcome.
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Sperm Retrieval
Oocyte activation
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Read the full review for this Faculty Opinions recommended article: Reproductive potential of men with obstructive azoospermia undergoing percutaneous sperm retrieval and intracytoplasmic sperm injection according to the cause of obstruction.
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Klinefelter syndrome is the most frequent chromosomal abnormality in patients with nonobstructive azoospermia. The development of advanced assisted reproductive techniques, such as testicular sperm extraction and intracytoplasmic sperm injection, has provided the possibility of biological fathering in nonobstructive azoospermic patients with Klinefelter syndrome. We aimed to evaluate our sperm retrieval rate by microdissection testicular sperm extraction and to analyse the intracytoplasmic sperm injection outcomes in these patients. Medical records of 110 nonobstructive azoospermic patients with Klinefelter syndrome were retrospectively reviewed. We found that the sperm retrieval rate by microdissection testicular sperm extraction is lower than published reports on other types of secretory azoospermia. The statistical analyses yielded that age, FSH and testosterone levels as predictive factors for successful sperm retrieval.
Sperm Retrieval
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Sperm Retrieval
Testicular sperm extraction
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Sperm Retrieval
Testicular sperm extraction
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Sperm Retrieval
Live birth
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Sperm Retrieval
Testicular sperm extraction
Obstructive azoospermia
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The couple from this clinical case consisted of a 55 years old male with an obstructive interval of 25 years post vasectomy, and a 38 years old female partner.Both partners had normal results in infertility workup.Five mature oocytes were injected with motile spermatozoa showing morphological alterations, obtained by percutaneous epididymal sperm aspiration.Four oocytes fertilized, and three embryos were transferred with assisted hatching on day three of development, of which one was a high-quality embryo.A clinical pregnancy was confirmed by the detection of two gestational sacs with foetal heartbeats.Pregnancy was ongoing during the submission of this manuscript.The use of ICSI with PESA/TESA should be considered as a feasible alternative when vasectomy reversal fails in vasectomized men wishing to father again.Case reports like this may inspire the counseling of couples that have suffered from a previous vasectomy reversal failure and support the recommendation of ICSI with PESA treatment, which could allow those couples to have their own children, even in the presence of advanced parental age.
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