Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy
19
Citation
24
Reference
10
Related Paper
Citation Trend
Abstract:
PURPOSE: To evaluate the neutrophil-to-lymphocyte ratio (NLR) levels to predict the severity of infl ammation in thyroid ophthalmopathy (TO).METHODS: Fifty-six patients with TO and 40 healthy subjects were included in this study.TO patients were divided into two groups according to clinical activity score (CAS).Group 1 included 24 active TO patients and Group 2 included 32 inactive TO patients.The thyroid status, white blood cell (WBC), neutrophil, and lymphocyte counts were performed.NLR was calculated by dividing the neutrophil count by the lymphocyte count.RESULTS: The mean age was 53.6 ± 5.4 in active TO group, 54.2 ± 5.6 in inactive TO group, and 52.7 ± 5.2 in the control group.The WBC, neutrophil, lymphocyte and NLR levels were higher in patients with TO than in the control group (p < 0.05).A signifi cant difference in NLR was found between the inactive and active TO groups (p < 0.05).CONCLUSION: NLR values were found to be higher in patients with TO than in controls.NLRvalues were also found higher in active TO patients than in inactive TO patients (Tab.3, Ref. 26).Keywords:
Absolute neutrophil count
White blood cell
Complete blood count
PURPOSE: To evaluate the neutrophil-to-lymphocyte ratio (NLR) levels to predict the severity of infl ammation in thyroid ophthalmopathy (TO).METHODS: Fifty-six patients with TO and 40 healthy subjects were included in this study.TO patients were divided into two groups according to clinical activity score (CAS).Group 1 included 24 active TO patients and Group 2 included 32 inactive TO patients.The thyroid status, white blood cell (WBC), neutrophil, and lymphocyte counts were performed.NLR was calculated by dividing the neutrophil count by the lymphocyte count.RESULTS: The mean age was 53.6 ± 5.4 in active TO group, 54.2 ± 5.6 in inactive TO group, and 52.7 ± 5.2 in the control group.The WBC, neutrophil, lymphocyte and NLR levels were higher in patients with TO than in the control group (p < 0.05).A signifi cant difference in NLR was found between the inactive and active TO groups (p < 0.05).CONCLUSION: NLR values were found to be higher in patients with TO than in controls.NLRvalues were also found higher in active TO patients than in inactive TO patients (Tab.3, Ref. 26).
Absolute neutrophil count
White blood cell
Complete blood count
Cite
Citations (19)
Objective: C-reactive protein, total White Blood Cell count and Absolute Neutrophil counts are important inflammatory markers. These tests are highly significant as predictor of bacterial infection in febrile children. Materials and Methods: We have collected data of 149 samples from pediatric indoor and outdoor patients. Samples were collected in both plain and EDTA vacuette. From plain vacuette CRP test was done and from EDTA vacuette total WBC count and absolute neutrophil count were done. Results: In present study we have collected data of 149 pediatric patient. Total number of patient having bacterial infection were 101. Out of which CRP positive samples were 91(90%), 56(55.4%) samples show leucocytosis and 36(35.6%) samples show neutrophilia. Conclusion: CRP test along with total WBC count and Absolute Neutrophil Count will be helpful for early prediction of bacterial infection and this test will guide clinician for better outcome of febrile children. Keywords: C-reactive protein, Total WBC count, Absolute Neutrophil count, Bacterial infection, Children.
Neutrophilia
Absolute neutrophil count
White blood cell
Complete blood count
Leukocytosis
Cite
Citations (0)
The efficacy of white blood cell (WBC) count and left shift in predicting bacterial infections has been controversial. The aim of this study was to prove that WBC count and left shift reflect a course of bacterial infection.Six patients in whom the onset of bacterial infection had been determined and successful treatment had been done were selected. Manual 100-cell differential counts were repeated at least every 24 hr.WBC count and left shift divided a course of bacterial infection into five phases. In the first phase of bacterial infection (0-10 hr after the onset), WBC count decreased to fewer than reference range without left shift. In the second phase (about 10-20 hr), low WBC count continued and left shift appeared. In the third phase (one to some days), WBC count increased above reference range with left shift. In the fourth phase (some to several days), high WBC count continued without left shift. In the fifth phase, WBC count went down into reference range without left shift.A combination of WBC count and left shift real-timely reflected a course of bacterial infection from the onset to healing. And we could judge which bacterial infection is adequately treated or not only by the above two routine laboratory tests.
White blood cell
Absolute neutrophil count
Complete blood count
Cite
Citations (30)
This retrospective study was aimed at revealing the incidence of normal white blood cell (WBC) count agranulocytosis in patients treated with antithyroid drugs (ATDs). From January 1975 to December 2001, 109 patients (0.35%) presented with ATD-induced agranulocytosis at our clinic. In 18 patients (16.5%), the WBC count exceeded 3.0 x 10(9)/L at the onset of agranulocytosis. Ten showed a downward trend in WBC count (3.0-3.9 x 10(9)/L) after the initiation of ATDs. Four had symptoms of infection. In the remaining 4 patients, routine WBC and granulocyte count monitoring detected an agranulocytosis. During the first 3 months of ATD treatment, 3347 patients (10.9%) had WBC count 3.0-3.9 x 10(9)/L even once with no symptom and normal granulocyte count and 26672 patients had WBC count >or= 4.0 x 10(9)/L with no symptom and normal granulocyte count. When agranulocytosis was found, twelve patients with normal WBC count agranulocytosis (0.36%) had WBC count 3.0-3.9 x 10(9)/L with no symptom, whereas only 2 patients with agranulocytosis (0.008%) had WBC count >or= 4.0 x 10(9)/L with no symptom. In conclusion, clinicians should take normal WBC count agranulocytosis into consideration at least during the first 3 months of antithyroid drug therapy, especially when WBC count is 3.0-3.9 x 10(9)/L.
White blood cell
Absolute neutrophil count
Leukopenia
Blood count
Complete blood count
Cite
Citations (114)
Late-onset sepsis in very low birth weight (VLBW) infants is a diagnostic challenge. We aimed to evaluate the diagnostic utility of the C-Reactive protein (CRP) and the complete blood count (CBC) for late-onset sepsis in VLBW infants. In a 5-year retrospective cohort of 416 VLBW infants born at less than 1500 g, there were 590 separate late-onset sepsis evaluations. CRP and CBC were drawn at time of initial blood culture (T0), at 16–24 h (T24) and 40–48 h (T48) after. The positive cut-off values for abnormal values were the following: CRP ≥10 mg/L and CBC with at least one anomaly, including white blood cell count < 5000/mm3, immature neutrophil/total neutrophil ratio > 0.10, or platelet count < 100,000/uL. Sensitivity and specificity for predicting late-onset sepsis were calculated for each laboratory test and their combinations. Receiver operating characteristics curves were obtained for each test and for the absolute change from T0 to T24 in the laboratory value of CRP, white blood cell count and immature neutrophil/total neutrophil. At T0, combining the CBC and the CRP had the highest sensitivity of 66% (95% confidence interval [CI], 58–73) compared to both individual tests for predicting late onset sepsis. At T24, CRP’s sensitivity was 84% (95% CI, 78–89) and was statistically higher than the CBC’s 59% (95% CI, 51–67). The combination of CBC at T0 and CRP at T24 offered the greatest sensitivity of 88% (95% CI, 82–92) and negative predictive value 93% (95% CI, 89–96), with fewer samples, compared to any other combination of tests. The area under the curve for the change in the white blood cell count from T0 to T24 was 0.82. At initial sepsis evaluation (T0), both CBC and CRP should be performed to increase sensitivity. A highly negative predictive value is reachable with only two tests: a CBC at T0 and a CRP a T24.
White blood cell
Absolute neutrophil count
Neonatal Sepsis
Complete blood count
Blood Culture
Cite
Citations (39)
Objective This study aimed to estimate the importance of complete blood count parameters for predicting the timing of birth in threatened preterm labour cases. Methods We performed a retrospective study of 92 patients who were diagnosed with threatened preterm labour (24–34 gestational weeks). The patients were divided into two groups according to the time of birth (group 1: delivered within the first week after diagnosis; group 2: delivered later than 1 week). We compared characteristics and complete blood count parameters between these two groups. Results There were no significant differences in maternal age, body mass index, gravida, parity, haemoglobin levels, and gestational weeks between the two groups. The mean cervical length was 24.24 ± 3.60 mm in group 1 and 30.70 ± 5.32 mm in group 2. There were significant differences in the neutrophil to lymphocyte ratio, white blood cell count, red cell distribution width (RDW), absolute lymphocyte cell count, and absolute neutrophil cell count between the two groups. Conclusion Maternal serum RDW, the neutrophil to lymphocyte ratio, white blood cell count, absolute lymphocyte cell count, and the absolute neutrophil cell count profile could guide clinicians in predicting the time of birth in threatened preterm labour cases.
White blood cell
Absolute neutrophil count
Complete blood count
Cite
Citations (12)
Prognostic factors in cancer patients provide information about possible clinical outcomes and help classify patients into different risk groups. Treatment and clinical management decisions are often challenging, thus the availability of reliable and accessible prognostic markers is vital when designing treatment plans and discussing them with patients. This article discusses the prognostic value of the complete blood cell count components (i.e., white blood cell count, absolute neutrophil count, absolute lymphocyte count, absolute monocyte count, hemoglobin level, and platelet count) in regard to clinical outcomes in patients with malignant disorders.
Absolute neutrophil count
White blood cell
Complete blood count
Blood count
Blood cell
Cite
Citations (22)
White blood cell (WBC) count and absolute neutrophil count (ANC) are a standard part of the evaluation of suspected appendicitis. Specific threshold values are utilized in clinical pathways, but the discriminatory value of WBC count and ANC may vary by age. The objective of this study was to investigate whether the diagnostic value of WBC count and ANC varies across age groups and whether diagnostic thresholds should be age-adjusted.This is a multicenter prospective observational study of patients aged 3-18 years who were evaluated for appendicitis. Receiver operator characteristic curves were developed to assess overall discriminative power of WBC count and ANC across three age groups: <5, 5-11, and 12-18 years of age. Diagnostic performance of WBC count and ANC was then assessed at specific cut-points.A total of 2,133 patients with a median age of 10.9 years (interquartile range = 8.0-13.9 years) were studied. Forty-one percent had appendicitis. The area under the curve (AUC) for WBC count was 0.69 (95% confidence interval [CI] = 0.61 to 0.77) for patients < 5 years of age, 0.76 (95% CI = 0.73 to 0.79) for 5-11 years of age, and 0.83 (95% CI = 0.81 to 0.86) for 12-18 years of age. The AUCs for ANC across age groups mirrored WBC performance. At a commonly utilized WBC cut-point of 10,000/mm3 , the sensitivity decreased with increasing age: 95% (<5 years), 91% (5-11 years), and 89% (12-18 years) whereas specificity increased by age: 36% (<5 years), 49% (5-12 years), and 64% (12-18 years).WBC count and ANC had better diagnostic performance with increasing age. Age-adjusted values of WBC count or ANC should be considered in diagnostic strategies for suspected pediatric appendicitis.
White blood cell
Absolute neutrophil count
Interquartile range
Complete blood count
Cite
Citations (18)
Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters.To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs.Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013. We included febrile (≥38°C), previously healthy, full-term infants younger than 60 days for whom blood cultures were obtained. All infants had either cerebrospinal fluid cultures or 7-day follow-up.We tested the accuracy of the white blood cell count, absolute neutrophil count, and platelet count at commonly used thresholds for IBIs. We determined optimal thresholds using receiver operating characteristic curves.Of 4313 enrolled infants, 1340 (31%; 95% CI, 30% to 32%) were aged 0 to 28 days, 2412 were boys (56%), and 2471 were white (57%). Ninety-seven (2.2%; 95% CI, 1.8% to 2.7%) had IBIs. Sensitivities were low for common complete blood cell count parameter thresholds: white blood cell count less than 5000/µL, 10% (95% CI, 4% to 16%) (to convert to 109 per liter, multiply by 0.001); white blood cell count ≥15 000/µL, 27% (95% CI, 18% to 36%); absolute neutrophil count ≥10 000/µL, 18% (95% CI, 10% to 25%) (to convert to × 109 per liter, multiply by 0.001); and platelets <100 × 103/µL, 7% (95% CI, 2% to 12%) (to convert to × 109 per liter, multiply by 1). Optimal thresholds for white blood cell count (11 600/µL), absolute neutrophil count (4100/µL), and platelet count (362 × 103/µL) were identified in models that had areas under the receiver operating characteristic curves of 0.57 (95% CI, 0.50-0.63), 0.70 (95% CI, 0.64-0.76), and 0.61 (95% CI, 0.55-0.67), respectively.No complete blood cell count parameter at commonly used or optimal thresholds identified febrile infants 60 days or younger with IBIs with high accuracy. Better diagnostic tools are needed to risk stratify young febrile infants for IBIs.
Blood count
Cite
Citations (81)