A new approach for one-pot, green synthesis of new polycyclic indoles in aqueous solution
6
Citation
21
Reference
10
Related Paper
Citation Trend
Keywords:
Environmentally Friendly
Phosphate buffered saline
Aqueous medium
This chapter presents a general overview of the progress achieved in the combination of a variety of well-established copper-catalyzed organic reactions (such as CuAAC reaction, CC and C–heteroatom coupling processes, and C–X activations) with the use of water as a green and environmentally friendly reaction media. In recent years, this combination has led to the development of a plethora of new greener synthetic methodologies, which try to maximize several Principles of Green Chemistry. Thus, this chapter tries to gather a family of ground-breaking contributions (more than a simple description of works reported in current literature) that show the great potential of using a first row, easily available and cheap metal (such as copper) in combination with an environmentally friendly solvent (water).
Environmentally Friendly
Aqueous medium
Heteroatom
Organic Synthesis
Coupling reaction
Cite
Citations (3)
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cite
Citations (0)
An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.
Electrochemical cell
Cite
Citations (92)
Abstract Several of the title compounds show promising cytotoxicities against cancer cells.
Cite
Citations (0)
The preferable application of green chemistry in research is to utilize environment benign, mild, non toxic, reproducible catalyst and efficient solvents in synthesis of molecules. Use of green chemistry techniques had enabled in dramatically reducing chemical waste and reaction times as has recently been reported in several organic syntheses reactions. Greener routes are required in the synthesis of N-heterocycles, due to the remarkable importance of these compounds in medicinal chemistry. This chapter is dedicated to the synthesis of N containing heterocyclic compounds using eco-friendly solvent like water and bio-derived solvents (glycerol, ethyl lactate, and gluconic acid aqueous solution). Water and bio-based solvents for the synthesis of aromatic nitrogen heterocycles was chosen due to the negligible toxicity associated with these solvents. Apart from being eco-friendly, water also has the potential to become a universally acceptable solvent due to its abundance and low cost. Work on microwave synthesis is also reported as it is an eco-friendly and faster process for the synthesis of these N-based heterocyclic compounds. Due to its rapid action to produce products with greater purity and yield, it is now being used worldwide.
Environmentally Friendly
Gluconic acid
Organic Synthesis
Cite
Citations (1)
With the increasing concerns of the environment, more and more chemists are devoted to the research of the which means that the reagent, solvent and catalyst are environmentally friendly in the organic chemical reactions. The importance of aqueous reaction is now generally recognized, and development of carbon-carbon bond-forming reactions that can be carried out in aqueous media is now one of the most challenging topics in organic synthesis.[1]Herein, we report a clean synthesis of 3,3,6,6-tetramethyl-9-aryl-1,8-dioxo-octahydroxanthene derivatives from aromatic aldehyde and 5,5-dimethyl-1,3-cyclohexadione using p-dodecylbenezenesulfonic acid (DBSA) as the catalyst in water.This method provides several advantages such as high yield, simple work-up procedure and environmental friendliness and water was chosen as a green solvent. All the products were characterized by m.p., 1H NMR, IR and elemental analyses.……
Environmentally Friendly
Aqueous medium
Organic Synthesis
Cite
Citations (0)
Highly substituted pyrido[4,3‐ b ]indole derivatives were synthesized through a straightforward one‐pot silver‐catalyzed process involving 2‐alkynylindole‐3‐carbaldehyde oximes. The tandem cyclization/nucleophilic addition sequence was optimized and applied to a wide range of nucleophiles, which reacted regioselectively at the pyrido[4,3‐ b ]indole C4 position. The scope and limitations of the methodology were evaluated and the final compounds were obtained in fair to very good yields. This versatile method proved to be compatible with various chemical functionalities or (hetero)cycles.
Tandem
Nucleophilic Addition
Surface Modification
Cite
Citations (11)
Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated
Imine
Cite
Citations (20)
Abstract Die Titelverbindungen (I) reagieren mit Nucleophilen unter Substitution der Acetoxy bzw. der Nitratgruppe zu den Produkten (II)‐(V).
Cite
Citations (0)
Abstract Small rate effects (acceleration and retardation) are observed in the solvolysis of (I) in the presence of nonbasic solutes such as NaClO 4 , NaI, NaSCN.
Solvolysis
Cite
Citations (0)