Reproductive outcomes according to estradiol levels on the day of gonadotropin-releasing hormone agonist triggering in oocyte donation cycles
Guillermo QueaClément JimenezA. CearsoloMiriam González‐GómezTeresa GanzabalInmaculada AusinSara QuevedoBeatriz Navarro Santana
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Keywords:
Hormone antagonist
Oocyte donation
Group B
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BACKGROUND: The main reason for adverse treatment outcome in assisted reproduction is the high rate of multiple pregnancies. The only strategy to avoid dizygotic twins is to transfer one embryo at a time. METHODS: A total of 144 women, who had had at least four good quality embryos available after IVF/intracytoplasmic sperm injection (ICSI) and who had no more than one previous failed treatment cycle, were randomized to have either one or two embryos transferred. The treatment outcomes including those after frozen embryo transfer were compared between these groups. RESULTS: The clinical pregnancy rate per transfer was 32.4% in the one embryo transfer group and 47.1% in the two embryo transfer group, the difference being not significant. Eleven twin deliveries (n = 39) occurred in the two embryo transfer group and there was one pair of monozygotic twins in the one embryo transfer group. The cumulative pregnancy rate per patient after transfer of fresh and frozen embryos was 47.3% in the one embryo transfer group and 58.6% in the two embryo transfer group. CONCLUSIONS: Our results indicate that among women who have good quality embryos in their first IVF/ICSI, good treatment results can be achieved. They support the idea of changing embryo transfer policy towards one embryo transfer without any remarkable decrease in the success rate, while dizygotic twins can be avoided.
Single Embryo Transfer
Monozygotic twin
Embryo quality
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Single Embryo Transfer
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Palpation
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[Objective] To investigate the effect of transabdominal ultrasound-guided embryo transfer on the outcome of in vitro fertilization-embryo transfer (IVF-ET). [Methods] The data of 461 patients undergoing IVF-ET (including intracytoplasmic sperm injection) therapy for 521 cycles in our Reproductive Medicine Center were analyzed retrospectively. The patients were divided into two groups: the traditional group (group A) and the ultrasound-guided group (group B), including 187 cycles and 334 cycles, respectively. The clinical pregnancy rate, implantation rate, embryo retention rate, and ectopic pregnancy rate between two groups were compared. [Results] The clinical pregnancy rates of group A and group B were 35.8% (67/187) and 38.3% (128/334), P 0.05; the implantation rates were 17.4% (104/599) and 23.2% (179/773), P 0.01; the embryo retention rates were 3.7% (7/187) and 0.3% (1/334), P 0.01; the ectopic pregnancy rates were 3.0% (2/67) and 1.6%(2/128), P 0.05.[Conclusion]Transabdominal ultrasound-guided ET can increase the implantation rate and decrease the embryo retention rate, may be helpful to improve the clinical pregnancy rate and decrease the ectopic pregnancy rate, so it is an effective technique for embryo transfer.
Assisted Reproductive Technology
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The rational of transferring two instead of three embryos was studied through 468 in-vitro fertilization (IVF) treatment cycles in 287 couples. The quality of 1224 embryos was determined according to the fragmentation rate and the morphology as good (A) and poor (B). The influence of the number of embryos transferred (two or three) on the pregnancy rate when the same quality or combinations of good and poor quality embryos transferred was examined. When only good quality embryos were transferred the pregnancy rates in double (AA) and triple (AAA) embryo transfer were 40.5 (17/42) and 42.9% (30/70) respectively (not significant). When only poor quality embryos were transferred, the pregnancy rates in double (BB) and triple (BBB) embryo transfers were 11.0% (11/100) and 22.9% (16/70) respectively (P < 0.001). On the other hand, when good and poor quality embryos were transferred together as AB in double and as AAB and ABB in triple embryo transfer, the pregnancy rates were 36.8 (14/38) and 39.9% (59/148) respectively (not significant). There was no difference in the miscarriage rate between double and triple embryo transfers; 16.7 and 18.1% respectively. The multiple pregnancy rate was 14.3% for double embryo transfers and 32.4% for triple embryo transfers (P < 0.001). This study demonstrates that if there is at least one good quality embryo available for transfer, then double instead of triple embryo transfer will not yield a significantly lower pregnancy rate. The influence of the number of embryos transferred on the pregnancy rate became significant when only poor quality embryos were transferred.(ABSTRACT TRUNCATED AT 250 WORDS)
Embryo quality
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BACKGROUND: The aim was to assess whether the type of embryo transfer set used for embryo transfer affects the ongoing pregnancy rate in IVF. METHODS: The TDT set was compared with the K-soft 5000 in a, large, prospective, randomized study. Patients were randomized moments before transfer by drawing a consecutively numbered, sealed, opaque envelope indicating the catheter to be used. RESULTS: 2059 embryo transfers in 1296 patients were analysed. The ongoing pregnancy rate was significantly higher in the K-soft group. If the first transfer of a patient (n = 1296) within this study period was analysed, the ongoing pregnancy rates were 27.1 versus 20.5% (P = 0.006). If the analysis is limited to patients that underwent their very first transfer ever (n = 607), the ongoing pregnancy rates were 30.3 versus 20.0% (P = 0.003) in favour of the K-soft. CONCLUSION: We conclude from these data that the type of embryo transfer set used for embryo transfer does affect the ongoing pregnancy rate and that the impact of the variable transfer catheter on the ongoing pregnancy rate increases when the a priori chance of pregnancy increases.
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Single Embryo Transfer
Embryo quality
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Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET)Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The related parameters were compared between conceived and non-conceived cycles.Results There were totally 129 clinical pregnancies in these transfers (pregnancy rate: 27.1％). Frozen-thawed embryos were transferred to natural cycles and CC cycling and hormone replacement treatment had equal success. Groups of IVF and ICSI did not differ significantly in pregnancy rates (P＞0. 05). The pregnancy rates for one, two, three and four pre-embryos transfer were 0, 20.0％,44.1％ and 75.0％,respectively (P＜0. 05). There were statistical differences between pregnancy group or non- pregnancy group in the endometrial thickness, CES, CES/No. Of embryo. A higher pregnancy rate was observed in embryo transfers which had at least one 4-cell grade I embryo (d 2)(P＜0.01). Conclusions The most important factors influencing the implantation rate and pregnancy rate of frozen-thawed embryo transfer are age, endometrium thickness, and the number, morphology and growth rate of transferred frozen embryos of women participants.
Embryo cryopreservation
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