[Assessment of global left ventricular function by 64-slice spiral CT in patients with old myocardial infarction].
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To investigate the clinical value of 64-slice spiral CT (64SCT) in assessing global left ventricular function in patients with old myocardial infarction (OMI), with magnetic resonance imaging (MRI) as the reference standard.A total of 28 patients (23 men and 5 women) with OMI underwent contrast-enhanced 64SCT with retrospective electrocardiographic-gating, MRI, and transthoracic echocardiography (Echo). The data sets of 64SCT and MRI were reconstructed at both end-diastole and end-systole to measure left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejective fraction (EF), and myocardial mass at end-diastole (MM). The data acquired with 64SCT and Echo were compared with the results obtained on MRI as the standard of reference respectively.The parameters of global left ventricular function obtained with 64SCT were significantly correlated with the MRI data (r = 0.788-0.976, P < 0.001). EDV, ESV, SV, EF, and MM were slightly overestimated by 64SCT compared with MRI; however, there was no significant difference among the measurements. 64SCT was in good agreement with MRI. For the EDV, ESV, SV, and EF, the limits of agreement with Echo were significantly larger than with 64SCT compared with MRI (P < 0.05). The sensitivity, specificity, and accuracy of 64SCT to identify EF value less than 50% were 84.6%, 100% and 92.9%, respectively, whereas those of Echo were 61.5%, 66.7% and 64.3%, respectively. The accuracy of 64SCT was significantly higher than that of Echo (P < 0.01). There was a significantly larger overestimation of EDV, ESV, and SV with Echo than with 64SCT compared with MRI (P < 0.05), whereas EF was not significantly different.A strong correlation between 64SCT and MRI is found for all parameters. 64SCT agrees well with MRI, and allows more reliable and accurate evaluation of global left ventricular function in patients with OMI than Echo compared with MRI.Keywords:
Multislice
End-diastolic volume
End-systolic volume
Systole
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Multidetector computed tomography
Neuroradiology
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Ziel: Vergleichende Bestimmung linksventrikulärer (LV) globaler und regionaler Funktionsparameter, Volumina und Wandstärkenänderungen sowie segmentale Analyse der Wandbewegung (WB) durch Dual-Source-CT (DSCT) und MRT. Methoden und Materialen: 30 Patienten mit bekannter oder vermuteter KHK, nichtobstruktiver HCM, DCM, ARVCM, Fallot-Tetralogie, kardialer Sarkoidose bzw. kardialen Metastasen unterzogen sich einer DSCT und MRT. Beide Untersuchungen wurden hinsichtlich endsystolischer (ESV) und -diastolischer (EDV) LV-Volumina, Schlagvolumina (SV), Ejektionsfraktion (EF) und myokardialer Masse (MM), der linksventrikulären Wanddickenzunahme sowie segmentaler Wandbewegung (Segmentmodell der AHA) statistisch ausgewertet. Ergebnisse: Die mittels DSCT bestimmten enddiastolischen (r = 0,96) und -systolischen Volumina (r = 0,98) korrelierten gut mit den MRT-Messungen. Die LV-EF (r = 0,97), SV (r = 0,83) und MM (r = 0,95) zeigten eine sehr gute Korrelation. Die Bland-Altman-Analyse zeigte eine geringe Unterschätzung der LV-EF (–1,1 ± 7,8 ml), EDV (–0.3 ± 18.2 ml) sowie Überschätzung von ESV (1.1 ± 7.8 ml) und MM (12.8 ± 14.4 g). Der systolische Rekonstruktionszeitpunkt wies eine gute Übereinstimmung (DSCT 32,2 ± 6,7 vs. MRT 35,6 ± 4,4 % RR-Intervall) auf. Die Wandstärke zeigte für alle LV Segmente eine gute Korrelation beider Modalitäten (mittlere Diff. 0,42 ± 1 mm). Störungen der WB wurden mit beiden Modalitäten in 413 Segmenten (89 %) übereinstimmend beurteilt, wobei die DSCT den Grad der Bewegungseinschränkung geringgradig unterschätzte. Schlussfolgerung: Die DSCT mit optimierter zeitlicher Auflösung ermöglicht die Analyse der regionalen und globalen LV-Funktion und die segmentbasierte Quantifizierung der regionalen WB in sehr guter Korrelation zur MRT. Dabei unterschätzt die DSCT den Grad der myokardialen Bewegungseinschränkung.
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Objective To assess functional parameters of left ventricle with 64-slice CT (MSCT) and the results were compared with MRI. Methods End-diastolic-volume (EDV), end-systolic-volume (ESV), stroke-volume (SV), ejection-fraction (EF), and myocardial mass (MM) were calculated based on CT data sets from 20 patients scheduled for noninvasive MSCT angiography of the coronaries suspected coronary artery disease (CAD). The results from MSCT were compared with MRI. Results There was no significant difference among the measurements for MSCT and MRI of the ventricular function parameters. A strong correlation between MSCT and MRI (r=0.72-0.92) was found for all parameters. However, EDV, ESV, SV, and MM were overestimated with MSCT compared to MRI, while EF was underestimated in MSCT. Conclusion A strong correlation between MSCT and MRI was found for all parameters. ECG-gated MSCT angiography of the heart is noninvasive assessment of the coronary tree, whereas the analysis of left ventricular parameters provides additional information of cardiac function without further radiation exposure or scan time.
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Objective: To evaluate the accuracy of real-time three-dimensional echocardiography(RT-3DE)for assessing left ventricular volume and function in coronary artery disease(CAD)patients with left ventricular aneurysm. Methods: A total of 116 CAD patients combined with left ventricular aneurysm were examined for their left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV)and left ventricular ejection fraction(LVEF)before and after the operation with two-dimensional echocardiography(2DE),RT-3DE and MRI respectively.The accuracy of 2DE and RT-3DE results were compared with MRI among different sized aneurysms. Results: ①In patients with small and medium size LV aneurysm,no real difference found between 2DE and RT-3DE with MRI for the above mentioned index,P0.05 respectively.②With large size LV aneurysm,LVDVE and LVDSE measured by 2DE before operation were different from MRI,P0.05 respectively.While pre-operative LVEF and other index after operation measured by 2DE weree no statistic differences from MRI;no differences between 3DE and MRI before and after the operation,P0.05 respectively.③With giant LV aneurysm,before the operation,the value of LVDVE and LVDSE measured by 2DE and RT-3DE were lower than MRI,and LVEF was higher than MRI,P0.05 respectively.After the operation,LVDVE and LVDSE measured by 2DE still lower than MRI,P0.05 respectively.There were no statistic difference for the above index between RT-3DE and MRI after the operation. Conclusion: Compared with 2DE,for large and giant LV aneurysm,RT-3DE examination is closer to MRI for assessing left ventricular volume and function,it is accurate and reliable.For giant LV aneurysm,left ventricular volume measured by 2DE and RT-3DE before the operation were both lower than MRI.
Ventricular aneurysm
Left Ventricular Aneurysm
End-systolic volume
Ventricular Function
Heart Aneurysm
End-diastolic volume
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Objective:To evaluate diagnostic accuracy of dual source computed tomography(DSCT) for evaluation of left ventricular(LV) function quantification in aortic valve replacement,with magnetic resonance imaging(MRI) as the reference standard.Methods:We evaluated a total of 21 patients(9 men,12 women;mean age years 56.7) who underwent both DSCT and MRI.Patients with aortic valve disease who were scheduled to undergo aortic valve replacement(AVR).Left ventricular ejection fraction,end-diastolic volume,endsystolic volume,stroke volume weremanually assessed for each patient by two blinded readers.Intraobserver variability was calculated using paired-samples t-test and interobserver variability was calculated using analysis of variance of repeated measure.Their agreement was measured using the intraclass correlation coefficient(ICC). Results:There was no significant difference among the measurements for DSCT and MRI of the ventricular function parameters.A strong correlation between DSCT and MRI(r=0.85~0.94) was found for all parameters.However,EDV,ESV,SVand EF were overestimated with DSCT compared to ICC in MRI(EDV,ESV,SV,EF) was 0.8~1,in DSCT(EDV,ESV,SV,EF) was 0.6~0.75,respectively.Conclusion:A strong correlation between DSCT and MRI is found for all parameters ECG-gated DSCT angiography can evaluate the coronary tree,whereas the analysis of left ventricular parameters provides additional information of cardiac function without further radiation exposure or scan time.
Valve replacement
Ventricular Function
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Objective To investigate the clinical value of 64-slice spiral CT(64SCT) in assessing left ventricular function.Methods A total of 35 patients were suspected or confirmed with coronary artery disease underwent ECG-gated enhanced 64SCT,left ventriculography(LVG) and echocardiography(Echo).The data sets of 64SCT,LVG and Echo were reconstructed at both end-diastole and end-systole to measure left ventricular end-diastolic volume(EDV),end-systolic volume(ESV),ejective fraction(EF).Three inspection methods lasted no more than a week.Results The parameters of left ventricular function(EDV,ESV,EF) obtained with 64SCT were significantly correlated with the Echo(r=0.85-0.90,P0.01).EDV and ESV were significantly overestimated by 64SCT compared with Echo(P0.05),whereas EF was not significantly different,consistency could be clinical acceptance.Evaluation of EDV,ESV,EF by linear regression analysis showed a good correlation between 64SCT and LVG,EF were significantly underestimated by 64SCT compared with LVG(P0.05).Conclusion EDV,ESV and EF determined by 64SCT have excellent correlation,good reproducibility and an fair agreement with LVG and Echo.64SCT is an accurate and reliable method in quantitative evaluation of left ventricular function.
Ventricular Function
Echo (communications protocol)
End-diastolic volume
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Objective:To study the accuracy of real-time 3-dimentional echocardiography(3-DE) in the evaluation of right ventricular function.Methods:Of 34 consecutive patients with clinically suspected or being diagnosed with pulmonary hypertension,real time 3-DE and MR scanning were performed within one week.The result of MRI was considered as the standard,and the accuracy of end-systolic volume(ESV),end-diastolic(EDV) and ejection fraction(EF) of right ventricle obtained by real time 3-DE were compared with that of MRI and analyzed.Results:Totally 30 patients accomplished both real time 3-DE and MR examination successfully.The ESV and EDV of right ventricle obtained by the two modalities had statistically significant differences(t=-4.97,P=0.00;t=-5.72,P=0.00 respectively),but no statistical difference was existed in the EF of right ventricle(t=-0.14,P=0.89).Conclusion:The EF of right ventricle measured by real time 3-DE was accurate and reliable,yet the accuracy of ESV and EDV of right ventricle measured by 3-DE had some difference compared with that of MRI,further improvement is needed.
Ventricular Function
End-systolic volume
Right heart
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Objective: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. Methods: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). Results: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 ± 37.6% and 136.4 ± 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. Conclusion: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.
Biplane
Ventricular Function
Cardiac cycle
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Objective To evaluate accuracy of cardiac magnetic resonance imaging(MRI) for assessing the left ventricular function compared with X-ray left ventriculography(LVG).Methods MRI and LVG were performed in 52 patients to estimate end-diastolic volume(EDV),end-systolic volume(ESV) and ejection fraction(EF) of left ventricle.Results The correlations between MRI and LVG for EDV,ESV and EF were 0.94,0.96 and 0.96 respectively(P0.001).The correlations in patients with myocardial infarction between MRI and LVG were 0.92,0.98 and 0.95(P0.001).The limits of agreement were(-22.4±32.4)ml,(-8.3±27.8)ml and(-2.5±8.6)% respectively.Correlations in patients with non-myocardial infarction between MRI and LVG were 0.95,0.95 and 0.98(P0.001).The limits of agreement were(-16.2±25.5)ml,(-1.8±25.1)ml and(-1.4±8.3)% respectively.Conclusion MRI is reliable and accurate to measure cardiac function.The results indicates MRI has a high correlation and agreement with LVG.
End-diastolic volume
Ventricular Function
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Introduction We evaluate the ability of 2D non‐contrast‐enhanced echocardiography ( CE ‐echo), 2 DCE ‐echo, 3D‐echo, 3D non‐ CE ‐echo, and 3 DCE ‐echo to evaluate allograft function and dimensions in orthotropic heart transplantation ( OHT ). Cardiac resonance ( CMR ) was used as reference. Methods Twenty six consecutive OHT ‐recipients were prospectively recruited. Bland–Altman, Spearman rank, and concordance‐correlation coefficients ( CCC ) were determined. Results Good CCC s were found between the four modalities and CMR for ejection fraction ( r ≥ 0.72/ P < 0.001; r ≥ 0.77/ P < 0.001; r ≥ 0.51/ P < 0.23; r ≥ 0.75/ P < 0.001, respectively). Highest intraclass correlation coefficient ( ICC ) was for 2D CE ‐echo( CCC = 0.77). End‐diastolic volume( EDV ) measurements statistically differed when 2D non‐ CE ‐echo, 2 DCE ‐echo, and 3D non‐ CE ‐echo were compared with the cross‐sectional imaging modalities, but they did not differ significantly from 3 DCE ‐echo. End‐systolic volume ( ESV ) and stroke volume ( SV ) differed statistically between the four modalities; however, SV measured by CMR and 3 DCE ‐echo were comparable. Overall, 2D non‐ CE ‐echo, 2 DCE ‐echo, and 3D non‐ CE ‐echo showed lower mean EDV , ESV , and SV than CMR . ICC was that of the ESV variable in the 4 techniques, with the values of the ICC of the 3 DCE ‐echo technique superior to the rest. Overall, the best CCC were found for 3 DCE ( r = 0.88, 0.92 and 0.76 for EDV , ESV and SV , respectively). Conclusion Routine use of 3 DCE ‐echo may allow more comprehensive cardiac assessment in cardiac transplant recipients.
Echo (communications protocol)
Concordance correlation coefficient
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