Evaluation of left ventricular function by using 64-slice spiral CT
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Objective To investigate the clinical value of 64-slice spiral CT(64SCT) in assessing left ventricular function.Methods A total of 35 patients were suspected or confirmed with coronary artery disease underwent ECG-gated enhanced 64SCT,left ventriculography(LVG) and echocardiography(Echo).The data sets of 64SCT,LVG and Echo were reconstructed at both end-diastole and end-systole to measure left ventricular end-diastolic volume(EDV),end-systolic volume(ESV),ejective fraction(EF).Three inspection methods lasted no more than a week.Results The parameters of left ventricular function(EDV,ESV,EF) obtained with 64SCT were significantly correlated with the Echo(r=0.85-0.90,P0.01).EDV and ESV were significantly overestimated by 64SCT compared with Echo(P0.05),whereas EF was not significantly different,consistency could be clinical acceptance.Evaluation of EDV,ESV,EF by linear regression analysis showed a good correlation between 64SCT and LVG,EF were significantly underestimated by 64SCT compared with LVG(P0.05).Conclusion EDV,ESV and EF determined by 64SCT have excellent correlation,good reproducibility and an fair agreement with LVG and Echo.64SCT is an accurate and reliable method in quantitative evaluation of left ventricular function.Keywords:
Ventricular Function
Echo (communications protocol)
End-diastolic volume
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To investigate the clinical value of 64-slice spiral CT (64SCT) in assessing global left ventricular function in patients with old myocardial infarction (OMI), with magnetic resonance imaging (MRI) as the reference standard.A total of 28 patients (23 men and 5 women) with OMI underwent contrast-enhanced 64SCT with retrospective electrocardiographic-gating, MRI, and transthoracic echocardiography (Echo). The data sets of 64SCT and MRI were reconstructed at both end-diastole and end-systole to measure left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejective fraction (EF), and myocardial mass at end-diastole (MM). The data acquired with 64SCT and Echo were compared with the results obtained on MRI as the standard of reference respectively.The parameters of global left ventricular function obtained with 64SCT were significantly correlated with the MRI data (r = 0.788-0.976, P < 0.001). EDV, ESV, SV, EF, and MM were slightly overestimated by 64SCT compared with MRI; however, there was no significant difference among the measurements. 64SCT was in good agreement with MRI. For the EDV, ESV, SV, and EF, the limits of agreement with Echo were significantly larger than with 64SCT compared with MRI (P < 0.05). The sensitivity, specificity, and accuracy of 64SCT to identify EF value less than 50% were 84.6%, 100% and 92.9%, respectively, whereas those of Echo were 61.5%, 66.7% and 64.3%, respectively. The accuracy of 64SCT was significantly higher than that of Echo (P < 0.01). There was a significantly larger overestimation of EDV, ESV, and SV with Echo than with 64SCT compared with MRI (P < 0.05), whereas EF was not significantly different.A strong correlation between 64SCT and MRI is found for all parameters. 64SCT agrees well with MRI, and allows more reliable and accurate evaluation of global left ventricular function in patients with OMI than Echo compared with MRI.
Multislice
End-diastolic volume
End-systolic volume
Systole
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Multidetector computed tomography
Neuroradiology
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Gated SPECT
Concentric hypertrophy
Emission computed tomography
End-systolic volume
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Objective:To compare of accuracy of cardiac magnetic resonance imaging(MRI),electrocardiogram-gated single-photon emission computed tomography(SPECT)and echocardiography with X-ray left ventriculography(LVG)in assessment of left ventricular function. Methods:LVG and MRI were performed in 46 patients,SPECT was performed in 30 patients,and echocardiography was per- formed in 38 patients,left ventricular function were estimated with MRI,SPECT and echocardiography.The results were com- pared with the gold standard of LVG.Statistical evaluation of correlation and agreement was done. Results:The correlation between MRI and LVG for end-diastolic volume,end-systolic volume and ejection fraction were 0.94,0.98 and 0.96,respectively(P＜0.001).The correlation ceefficiency between SPECT and LVG were 0.82,0.90 and 0.93 (P＜0.001).The correlation ceefficiency between echocardiography and LVG were 0.66,0.74 and 0.69(P＜0.001).The lim- its of agreement of end-diastolic volume,end-systolic volume and ejection fraction between MRI and LVG were(-21.4±31.8) ml,(-7.7±25.0)ml and(-2.2±8.8)%,respectively.The limits of agreement between SPECT and LVG were(-36.8±53.1)ml,(-15.2±32.2)ml and(-2.6±11.0)%,respectively.The limits of agreement between echocardiography and LVG were(-80.9±95.8)ml,(-47.5±96.0)ml and(3.6±21.1)%,respectively. Conclusion:MRI is reliable and accurat in measuring cardiac function,and shows a high correlation and agrrement between MRI and LVG.It also shows a good correlation but mild agrrement between SPECT and LVG.However,the value in measuring left ventricular function is deviated by echocardiography.
Emission computed tomography
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Objective:To study the accuracy of real-time 3-dimentional echocardiography(3-DE) in the evaluation of right ventricular function.Methods:Of 34 consecutive patients with clinically suspected or being diagnosed with pulmonary hypertension,real time 3-DE and MR scanning were performed within one week.The result of MRI was considered as the standard,and the accuracy of end-systolic volume(ESV),end-diastolic(EDV) and ejection fraction(EF) of right ventricle obtained by real time 3-DE were compared with that of MRI and analyzed.Results:Totally 30 patients accomplished both real time 3-DE and MR examination successfully.The ESV and EDV of right ventricle obtained by the two modalities had statistically significant differences(t=-4.97,P=0.00;t=-5.72,P=0.00 respectively),but no statistical difference was existed in the EF of right ventricle(t=-0.14,P=0.89).Conclusion:The EF of right ventricle measured by real time 3-DE was accurate and reliable,yet the accuracy of ESV and EDV of right ventricle measured by 3-DE had some difference compared with that of MRI,further improvement is needed.
Ventricular Function
End-systolic volume
Right heart
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Present study was designed to evaluate the accuracy of the measurement of left ventricular volume by quantitative gated SPECT (QGS) software using 201T1 and the effect of cutoff frequency of Butterworth prereconstruction filter on the calculation of volume.The RH-2 type cardiac phantom and 20 patients with ischemic heart disease were studied. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) were calculated by the QGS software using the various frequency of Butterworth filter. These parameters were evaluated by Simpson's method using left ventriculography (LVG).The volume of the phantom calculated by QGS was under-estimated by 14%. In the clinical study, EDV and ESV measured by QGS were smaller than those obtained from LVG by 10%. When the cutoff frequency of Butterworth filter was 0.43 cycles/cm, the values measured by QGS were best correlated with those by LVG (EDV: r = 0.80, p < 0.001; ESV: r = 0.86, p < 0.001; EF: r = 0.80, p < 0.001).These data suggest that 201Tl quantitative gated cardiac SPECT can estimate myocardial ischemia and left ventricular function simultaneously.
Gated SPECT
Thallium
Ventricular volume
Cut-off
Cardiac cycle
Ventricular Function
End-systolic volume
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Objective: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. Methods: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). Results: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 ± 37.6% and 136.4 ± 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. Conclusion: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.
Biplane
Ventricular Function
Cardiac cycle
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Objective To evaluate accuracy of cardiac magnetic resonance imaging(MRI) for assessing the left ventricular function compared with X-ray left ventriculography(LVG).Methods MRI and LVG were performed in 52 patients to estimate end-diastolic volume(EDV),end-systolic volume(ESV) and ejection fraction(EF) of left ventricle.Results The correlations between MRI and LVG for EDV,ESV and EF were 0.94,0.96 and 0.96 respectively(P0.001).The correlations in patients with myocardial infarction between MRI and LVG were 0.92,0.98 and 0.95(P0.001).The limits of agreement were(-22.4±32.4)ml,(-8.3±27.8)ml and(-2.5±8.6)% respectively.Correlations in patients with non-myocardial infarction between MRI and LVG were 0.95,0.95 and 0.98(P0.001).The limits of agreement were(-16.2±25.5)ml,(-1.8±25.1)ml and(-1.4±8.3)% respectively.Conclusion MRI is reliable and accurate to measure cardiac function.The results indicates MRI has a high correlation and agreement with LVG.
End-diastolic volume
Ventricular Function
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Background: Measurement of left ventricular (LV) volumes and ejection fraction (EF) is important in managing patients with coronary artery disease (CAD). Introduction of free‐hand three‐dimensional echocardiography (3DE) system which is equipped with small magnetic tracking system and average rotational geometry for LV volumes may provide easy and accurate quantification of LV systolic function in CAD patients. Purpose: To evaluate the feasibility and accuracy of LV volumes and EF measurement by free‐hand 3DE with rotational geometry in patients with CAD. Methods and Results: The study subjects consisted of consecutive 25 patients with CAD who were scheduled for quantitative gated single‐photon emission computed tomography (QGS). LV end‐diastolic volume (EDV), end‐systolic volume (ESV), and EF were determined by conventional two‐dimensional echocardiography (2DE), 3DE, and QGS. Three‐dimensional echocardiography data acquisition and analysis were possible in 22 of 25 subjects (feasibility 88%). In this 3DE system, image acquisition time was 2 minutes, and 5 minutes were needed for off‐line analysis of LV volumes and EF. Correlations and the limits of agreement between 3DE and QGS (r = 0.97, 0.0 ± 9.1 ml for EDV, r = 0.99, 0.0 ± 5.0 ml for ESV, and r = 0.97, 0.5 ± 3.3% for EF, respectively) were superior to those between 2DE and QGS (r = 0.85, 12.6 ± 26.8 ml for EDV, r = 0.85, 9.7 ± 26.1 ml for ESV, and r = 0.90, −1.3 ± 6.9% for EF, respectively). Inter‐ and intra‐observer variabilities of 3DE were smaller than that of 2DE (5% vs 10%, 5% vs 10% for EDV, 6% vs 13%, 5% vs 9% for ESV, and 4% vs 11%, 4% vs 6% for EF, respectively). Conclusion: Three‐dimensional echocardiography using magnetic tracking system and average rotational geometry offered a feasible and accurate method for quantification of LV volumes and EF in patients with CAD.
Ventricular Function
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Objective To assess the correlations between multislice computed tomography (MSCT) and echocardiography in assessment of left ventricular myocardial function, and to compare the results with magnetic resonance imaging (MRI). Materials and Methods End-diastolic-volume (EDV), end-systolic-volume (ESV), stroke-volume (SV), ejection-fraction (EF), and myocardial mass (MM) were calculated from 32 patients scheduled for MSCT angiography of the coronaries suspected of coronary artery disease (CAD).The results from MSCT and echocardiography were compared with MRI.Results There was no significant difference among the measurements for MSCT and MRI of the ventricular function parameters. A strong correlation between MSCT and MRI (r=0.78～0.92) was found for all parameters. There was also no significant difference among the measurements for echocardiography and MRI of the ventricular function parameters. Echocardiography and MRI had good correlation for EDV (r=0.63) and SV (r=0.69), and a low or moderate correlation for ESV (r=0.41), and EF (r=0.34) .However, EDV, ESV, SV, and MM were overestimated with MSCT compared to MRI, while EF was underestimated in MSCT. Echocardiography revealed overestimation of EF and an underestimation of EDV and ESV.Conclusion A strong correlation between MSCT and MRI is found for all parameters. ECG-gated MSCT angiography can evaluate the coronary tree, whereas the analysis of left ventricular parameters provides additional information of cardiac function without further radiation exposure or scan time. Moreover, the functional analysis with MSCT is more accurate than that with echocardiography.
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